Treatment of dental and orthodontic complications in thalassaemia.
Treatment of dental and orthodontic complications in thalassaemia.
复制标题
地中海贫血的牙科和正畸并发症的治疗。
DOI：
10.1002/14651858.cd012969.pub3
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Kulkarni,Palna
中科院分区：
文献类型：
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作者：
Mulimani,Priti;Abas,AdinegaraBl;Karanth,Laxminarayan;Colombatti,Raffaella;Kulkarni,Palna
研究背景地中海贫血是由控制α或β球蛋白产生的基因突变引起的血红蛋白数量异常。不正常的未配对珠蛋白链会导致器官系统内的膜损伤和细胞死亡，以及骨髓中红细胞前体的破坏，从而导致溶血性贫血。地中海贫血的一般健康影响的终身管理极具挑战性，未能处理牙齿和正畸并发症加剧了该疾病的公共卫生，经济和个人负担。目前缺乏循证指南来帮助护理寻求者和提供者管理此类牙科和正畸并发症。本综述旨在评估地中海贫血患者牙齿和正畸并发症治疗方法的现有证据，以告知未来的建议。这是对2019年首次发表的科克伦综述的更新。目标
BackgroundThalassaemia is a quantitative abnormality of haemoglobin caused by mutations in genes controlling production of alpha or beta globins. Abnormally unpaired globin chains cause membrane damage and cell death within organ systems and destruction of erythroid precursors in the bone marrow, leading to haemolytic anaemia. The life‐long management of the general health effects of thalassaemia is highly challenging, and failure to deal with dental and orthodontic complications exacerbates the public health, financial and personal burden of the condition. There is a lack of evidence‐based guidelines to help care seekers and providers manage such dental and orthodontic complications. This review aimed to evaluate the available evidence on methods for treating dental and orthodontic complications in people with thalassaemia to inform future recommendations. This is an update of a Cochrane Review first published in 2019.Objectives