THE ROLE OF INSULIN IN FETAL GROWTH
THE ROLE OF INSULIN IN FETAL GROWTH
复制标题
DOI：
10.1016/0378-3782(92)90135-4
复制
发表时间：
1992-06-01
影响因子：
2.5
通讯作者：
FOWDEN, AL
中科院分区：
文献类型：
--
作者：
FOWDEN, AL
胎儿胰岛素分泌紊乱与多种物种的胎儿生长异常有关：胰岛素分泌过多可导致巨大儿，而胎儿低胰岛素血症总是导致胎儿生长迟缓。羊胎儿胰腺切除术（PX）引起的胎儿胰岛素缺乏症导致分娩时体重、头臀长和四肢长减少。PX后子宫内生长速度下降40-50%，通过胰岛素替代治疗可恢复正常值。这些生长变化伴随着羊胎对葡萄糖的脐吸收、利用和氧化率降低30-40%。因此，胰岛素是胎儿生长的生理调节剂，部分通过刺激细胞摄取葡萄糖及其在胎儿组织中优先用于氧化代谢来发挥作用。
Disturbances in fetal insulin secretion are associated with abnormalities in fetal growth in a variety of species: excessive insulin secretion can lead to fetal macrosomia while fetal hypoinsulinaemia invariably causes fetal growth retardation. Fetal insulin deficiency caused by pancreatectomy (PX) of the sheep fetus leads to reduced body weight, crown-rump length and limb lengths at delivery near term. The growth rate in utero fell by 40-50% after PX and could be restored to normal values by insulin replacement treatment. These changes in growth were accompanied by reductions of 30-40% in the rates of umbilical uptake, utilization and oxidation of glucose by the sheep fetus. Insulin is therefore a physiological regulator of fetal growth and acts in part by stimulating the cellular uptake of glucose and its preferential use for oxidative metabolism in the fetal tissues.