THE ESTABLISHMENT OF NORMAL LIMITS FOR SERUM-PROTEINS MEASURED BY THE RATE NEPHELOMETER - CONCEPTS OF NORMALITY REVISITED
THE ESTABLISHMENT OF NORMAL LIMITS FOR SERUM-PROTEINS MEASURED BY THE RATE NEPHELOMETER - CONCEPTS OF NORMALITY REVISITED
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DOI：
10.1016/s0046-8177(81)80258-4
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发表时间：
1981-01-01
期刊：
影响因子：
3.3
通讯作者：
PATIL, K
中科院分区：
文献类型：
--
作者：
HAPKE, M;PATIL, K
研究了人的免疫球蛋白、免疫球蛋白M、免疫球蛋白A、补体C3[补体成分3]C4和结合珠蛋白在两个地理位置不同的健康人群中的分布情况。通过几种统计正态检验对这些数据的评估表明，这些检验在能力上是不同的；即，在其他情况下，被拒绝为高斯的数据可以被接受。没有规则确定在给定情况下应用哪种测试是最好的。.hivin.x.+-的非关键应用。2临床实验室检测参考范围的标准偏差可能不可靠，在许多情况下可能不明显，也可能无法提供临床有用的信息。一项大规模的临床研究旨在经验地获得不同实验室检测的限度，以及针对不同疾病状态所需的特异性和敏感度水平，可能会被证明是有益的，并产生更多对临床有用的知识。在进行这样的调查之前，建议通过非参数百分位数估计(2.5-97.5%)来确定参考范围，这种估计不对数据在总体中的分布做出任何预先假设。
The distribution of nephelometrically determined data for human IgG, IgM, IgA, C3 [complement component 3] C4 and haptoglobin was studied in 2 geographically separate, healthy populations. Evaluation of these data by several tests of statistical normality revealed that the tests vary consideraby in power; i.e., data rejected as gaussian in other cases may be accepted. No rules determine which is the best test to apply in a given situation. The uncritical application of .hivin.X .+-. 2 SD for the reference range of clinical laboratory tests may be unreliable, which may not be obvious and may not provide clinically useful information in many cases. A large scale clincial investigation designed to empirically obtain limits of different laboratory tests with desired levels of specificity and sensivity for diferent disease states may prove rewarding and yield knowledge more useful for clinical purposes. Until such an investigation is carried out, determination of reference ranges by a nonparametric percentile estimate (2.5-97.5%), which makes no prior assumptions about the distribution of the data in the population, is recommended.