Microbubbles from Gas-Generating Perfluorohexane Nanoemulsions for Targeted Temperature-Sensitive Ultrasonography and Synergistic HIFU Ablation of Tumors
Microbubbles from Gas-Generating Perfluorohexane Nanoemulsions for Targeted Temperature-Sensitive Ultrasonography and Synergistic HIFU Ablation of Tumors
复制标题
气体微泡 — 生成用于目标温度的全氟己烷纳米乳剂 — 敏感超声检查和协同 HIFU 消融肿瘤
DOI：
10.1002/adma.201301655
复制
发表时间：
2013-08-14
影响因子：
29.4
通讯作者：
Zheng, Yuanyi
中科院分区：
文献类型：
--
作者：
Zhou, Yang;Wang, Zhigang;Zheng, Yuanyi
通过设计靶向纳米乳剂，开发了一种基于“声学液滴汽化（ADV）”机制的特殊“小到大”温度响应相变策略，用于高效靶向超声检查和协同高强度聚焦超声（HIFU）癌症手术，并在体外、离体和体内进行了系统评估和成功验证。
A special" small to big" temperature-responsive phase-transformation strategy based on the" acoustic droplet vaporization (ADV)" mechanism is developed for efficient targeted ultrasonography and synergistic high intensity focused ultrasound (HIFU) cancer surgery by engineering targeted nanoemulsions, which is systematically evaluated and successfully demonstrated in vitro, ex vivo, and in vivo.