Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing.
Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing.
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DOI：
10.1523/jneurosci.0564-11.2011
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发表时间：
2011-06-15
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影响因子：
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通讯作者：
Feller MB
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文献类型：
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作者：
Rivlin-Etzion M;Zhou K;Wei W;Elstrott J;Nguyen PL;Barres BA;Huberman AD;Feller MB
开关方向选择性视网膜神经节细胞（DSGC）编码视觉运动轴。它们对沿首选方向移动的物体反应强烈，对沿相反“零”方向移动的物体反应较弱。历史上，开关 DSGC 根据其方向偏好（前、后、上或下）分为 4 种亚型。在这里，我们比较了两个基因鉴定的 On-Off DSGC 群体：DRD4-DSGC 和 TRHR-DSGC。我们发现，尽管这两个群体都适合后向运动，但它们可以通过各种生理和解剖标准来区分。首先，TRHR-DSGC 的定向调谐比 DRD4-DSGC 的定向调谐更广泛。其次，虽然两个群体的投影与背外侧膝状核相似，但它们与腹外侧膝状核和上丘的投影不同。此外，TRHR-DSGC（但不是 DRD4-DSGC）也投射到未定带，这是一个以前不知道接收方向调整视觉信息的丘脑区域。我们的研究结果揭示了小鼠 On-Off DSGC 亚型之间意想不到的多样性，这些亚型能够独特地处理图像运动并将其传递给大脑。
On-Off direction selective retinal ganglion cells (DSGCs) encode the axis of visual motion. They respond strongly to an object moving in a preferred direction and weakly to an object moving in the opposite, ‘null’, direction. Historically, On-Off DSGCs were classified into 4 subtypes according to their directional preference (anterior, posterior, superior or inferior). Here, we compare two genetically identified populations of On-Off DSGCs: DRD4-DSGCs and TRHR-DSGCs. We find that although both populations are tuned for posterior motion, they can be distinguished by a variety of physiological and anatomical criteria. First, the directional tuning of TRHR-DSGCs is broader than that of DRD4-DSGCs. Second, whereas both populations project similarly to the dorsal lateral geniculate nucleus, they project differently to the ventral lateral geniculate nucleus and the superior colliculus. Moreover, TRHR-DSGCs, but not DRD4-DSGCs, also project to the zona incerta, a thalamic area not previously known to receive direction-tuned visual information. Our findings reveal unexpected diversity among mouse On-Off DSGC subtypes that uniquely process and convey image motion to the brain.