Specificity of quantitative EEG analysis in adults with attention deficit hyperactivity disorder
Specificity of quantitative EEG analysis in adults with attention deficit hyperactivity disorder
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DOI：
10.1016/s0165-1781(02)00190-7
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发表时间：
2002-10-10
影响因子：
11.3
通讯作者：
Barry, RJ
中科院分区：
文献类型：
--
作者：
Bresnahan, SM;Barry, RJ
儿童和青少年的注意力缺陷多动障碍（ADHD）的特点是过度不安和极差的注意力集中范围，导致冲动和破坏性行为。对成人ADHD的临床观察表明，早期多动对社会和学术功能的影响减少，而冲动型行为保持不变。对ADHD儿童和青少年的EEG研究表明，与正常受试者相比，他们的低频功率（主要是θ波）明显增加，高频功率（主要是β波）减少。在正常儿童和青少年中，随着年龄的增长，θ功率降低，β功率增加，导致一些研究人员将ADHD的EEG异常解释为发育迟缓的证据。与正常成人对照受试者相比，ADHD成人的研究发现两组之间的差异减少，这表明ADHD儿童和青少年中明显减少的β活性随年龄而变化。因此，ADHD成人似乎具有升高的低频功率作为其与正常对照受试者的主要EEG差异。本研究探讨了这种脑电图特征是否特异于成人ADHD患者。定量脑电图记录在休息时，在一个睁着眼睛的条件下，并用于比较50名成人患者诊断为ADHD与50名非ADHD受试者（谁提出的ADHD评估，但不符合诊断标准）和50名对照组。ADHD组与非ADHD组和对照组的不同之处在于θ活动的升高。ADHD和对照组在β活动方面没有差异，但与ADHD和对照组相比，非ADHD组的相对θ降低，相对β功率升高。这些结果表明，定量脑电图可用于区分ADHD成人与正常成人和成人谁显示的ADHD的一些症状，但不符合ADHD的诊断标准。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Attention deficit hyperactivity disorder (ADHD) in children and adolescents is characterised by excessive restlessness and an extremely poor concentration span, resulting in impulsive and disruptive behaviour. Clinical observation of ADHD in adults suggests that the early hyperactivity is diminished in terms of its impact on social and academic function, while impulsive-type behaviours remain unchanged. EEG studies in children and adolescents with ADHD have reported significantly more low-frequency power (predominantly theta) and less high-frequency power (predominantly beta) than in normal subjects. In normal children and adolescents, a decrease in theta power and an increase in beta power are found with increasing age, leading some researchers to interpret the EEG anomalies in ADHD as evidence of developmental delay. Studies of adults with ADHD compared with normal adult control subjects have found a reduction in the difference between the two groups, suggesting that the reduced beta activity apparent in ADHD children and adolescents changes with age. Adults with ADHD thus appear to have elevated low-frequency power as their predominant EEG difference from normal control subjects. The present study examined whether this EEG profile was specific to adult ADHD patients. Quantitative EEGs were recorded at rest in an eyesopen condition and used to compare 50 adult patients diagnosed with ADHD with 50 non-ADHD subjects (who presented for ADHD assessment but failed to meet the diagnostic criteria) and 50 control subjects. The ADHD group differed from both the non-ADHD and the control groups on the basis of elevated theta activity. The ADHD and control groups did not differ in beta activity, but relative theta was reduced and relative beta power was elevated in the non-ADHD group compared with both the ADHD and control groups. These results suggest that quantitative EEG may be used to differentiate ADHD adults from both normal adults and adults who display some of the symptoms of ADHD, but fail to meet the diagnostic criteria of ADHD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.