Gut-training: the impact of two weeks repetitive gut-challenge during exercise on gastrointestinal status, glucose availability, fuel kinetics, and running performance
Gut-training: the impact of two weeks repetitive gut-challenge during exercise on gastrointestinal status, glucose availability, fuel kinetics, and running performance
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DOI：
10.1139/apnm-2016-0453
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发表时间：
2017-05-01
影响因子：
3.4
通讯作者：
Gibson, Peter
中科院分区：
文献类型：
--
作者：
Costa, Ricardo J. S.;Miall, Atlanta;Gibson, Peter
由于胃肠道的适应性，本研究旨在确定超过2周的肠道训练方案对胃肠道状态、血糖可用性、燃料动力学和跑步性能的影响。耐力跑者（n = 25）进行了一项肠道挑战试验（GC1），包括以60% VO2max进行2小时跑步运动，同时每20分钟消耗含有30克碳水化合物（2:1葡萄糖/果糖，10% w/ v）的凝胶片和1小时距离测试。然后，参与者被随机分配到碳水化合物凝胶-盘（CHO-S）、碳水化合物食物（CHO-F）或安慰剂（PLA）肠道训练组，进行为期2周的重复肠道挑战干预。然后，参与者重复了第二次肠道挑战试验（GC2）。CHO-S组胃肠道症状减轻（60%,p = 0.008）， CHO-F组胃肠道症状减轻（63%,p = 0.046）；减少量大于PLA （p < 0.05）。与CHO-F （9 (6-12) ppm）和PLA (12 (2-21) ppm)（试验x时间：p < 0.001）相比，CHO-S（平均（CI）： 6 (4-8) ppm）在GC2中H-2峰较低。GC2对CHO-S的血糖浓度升高（7.2 (6.3-8.1)mmol）。L-1)与CHO-F (6.1 (5.7-6.5) mmol相比。L-1)和PLA (6.2 (4.9-7.5) mmol。L-1)（试验x时间：p = 0.015）。各组和试验之间氧化率、血浆I-FABP和皮质醇浓度均无差异。距离试验改善了GC2患者CHO-S（5.2%）和CHO-F(4.3%)，但对PLA（-2.1%）没有改善（试验x时间：p = 0.009）。与PLA相比，用CHO-S和CHO-F进行两周的肠道训练可改善胃肠道症状和跑步表现。与PLA相比，CHO-S还减少了耐力跑步时的吸收不良，并增加了血糖利用率。
Due to gastrointestinal tract adaptability, the study aimed to determine the impact of gut-training protocol over 2 weeks on gastrointestinal status, blood glucose availability, fuel kinetics, and running performance. Endurance runners (n = 25) performed a gut-challenge trial (GC1), consisting of 2 h running exercise at 60% VO2max whilst consuming gel-discs containing 30 g carbohydrates (2: 1 glucose/ fructose, 10% w/ v) every 20 min and a 1 h distance test. Participants were then randomly assigned to a carbohydrate gel-disc (CHO-S), carbohydrate food (CHO-F), or placebo (PLA) gut-training group for 2 weeks of repetitive gut-challenge intervention. Participants then repeated a second gut-challenge trial (GC2). Gastrointestinal symptoms reduced in GC2 on CHO-S (60%; p = 0.008) and CHO-F (63%; p = 0.046); reductions were greater than PLA (p < 0.05). H-2 peak was lower in GC2 on CHO-S (mean (CI): 6 (4-8) ppm) compared with CHO-F (9 (6-12) ppm) and PLA (12 (2-21) ppm) (trial x time: p < 0.001). Blood glucose concentration was higher in GC2 on CHO-S (7.2 (6.3-8.1) mmol . L-1) compared with CHO-F (6.1 (5.7-6.5) mmol . L-1) and PLA (6.2 (4.9-7.5) mmol . L-1) (trial x time: p = 0.015). No difference in oxidation rates, plasma I-FABP, and cortisol concentrations were observed between groups and trials. Distance test improved on CHO-S (5.2%) and CHO-F (4.3%) in GC2, but not on PLA (-2.1%) (trial x time: p = 0.009). Two weeks of gut-training with CHO-S and CHO-F improved gastrointestinal symptoms and running performance compared with PLA. CHO-S also reduced malabsorption and increased blood glucose availability during endurance running compared with PLA.