Laryngeal afferent inputs to the nucleus of the solitary tract.
Laryngeal afferent inputs to the nucleus of the solitary tract.
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喉部传入孤束核。
DOI：
10.1152/ajpregu.1993.265.2.r269
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Mifflin,SW
中科院分区：
文献类型：
--
作者：
Mifflin,SW
下面的研究是为了检查喉传入输入在孤立束核（NTS）内的整合，孤立束核是喉传入纤维的主要终点。通过兴奋性突触后电位（EPSP, n = 49）、兴奋性-抑制性突触后电位（EPSP-IPSP）序列（n = 13）或IPSP （n = 1）对喉上神经（SLN）电刺激有反应的63个细胞获得细胞内记录。机械刺激喉部机械感受器显示出多种反应模式（如缓慢和快速适应去极化或超极化）。随着SLN刺激频率的增加，观察到两种类型的反应。在11个细胞中，sln诱发的10 Hz EPSP振幅仅为1 Hz振幅的47 +/- 4%，而在6个细胞中，10 Hz EPSP振幅与1 Hz几乎相同（93 +/- 3%）。在膜电位没有变化的情况下，SLN输入到NTS神经元之间的时间依赖性抑制相互作用发生在间隔为50 ~ 400 ms之间。NTS神经元对喉机械感受器的短暂激活的反应与喉机械感受器的放电模式相对应。频率依赖的过滤和时间依赖的抑制相互作用可能会改变NTS神经元在更强烈的喉传入刺激时的反应。
The following study was undertaken to examine the integration of laryngeal afferent inputs within the nucleus of the solitary tract (NTS), the primary site of termination of laryngeal afferent fibers. Intracellular recordings were obtained from 63 cells that responded to electrical stimulation of the superior laryngeal nerve (SLN) with an excitatory postsynaptic potential (EPSP; n = 49), an excitatory-inhibitory postsynaptic potential (EPSP-IPSP) sequence (n = 13), or an IPSP (n = 1). Mechanical stimulation of laryngeal mechanoreceptors revealed a variety of response patterns (e.g., slowly and rapidly adapting depolarizations or hyperpolarizations). Two types of response to increasing SLN stimulus frequency were observed. In 11 cells SLN-evoked EPSP amplitude at 10 Hz was only 47 +/- 4% of the amplitude at 1 Hz, while in 6 cells EPSP amplitude at 10 Hz was virtually identical (93 +/- 3%) to that at 1 Hz. Time-dependent inhibitory interactions occurred between SLN inputs to NTS neurons at intervals between 50 and 400 ms and in the absence of any change in membrane potential. NTS neuronal responses to brief activation of laryngeal mechanoreceptors correspond well to discharge patterns described for individual laryngeal mechanoreceptors. Frequency-dependent filtering and time-dependent inhibitory interactions might modify NTS neuronal responses during more intense stimulation of laryngeal afferents.