Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature
Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature
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DOI：
10.1016/j.ijom.2010.01.007
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发表时间：
2010-03-01
影响因子：
2.4
通讯作者：
Shibahara, T.
中科院分区：
文献类型：
--
作者：
Takano, J. H.;Yakushiji, T.;Shibahara, T.
本研究的目的是利用窄带成像(NBI)系统分析和描述早期口腔肿瘤病变的特征之一--乳头内毛细血管环(IPCL)。对41例非肿瘤性或肿瘤性病变的患者(男性26例，女性15例；平均年龄52.34岁；年龄23-83岁)和正常患者进行了Evis Lucera频谱原型(奥林巴斯公司)的检查。对图像进行了分析，并设计了IPCL分类。所有正常病例(n=10)均有规则分布的相同形状(I型)的毛细血管环。非肿瘤性病变(8例)毛细血管环轻度改变(II、II型)，肿瘤性病变(23例)呈不规则分布，呈多种环状(III、IV型)。非肿瘤性病变的微血管组织与肿瘤性病变的微血管组织明显不同。5例早期癌为棕色区。窄带成像系统是临床分析微血管组织和IPCL的一种潜在方法。对口腔鳞状细胞癌的早期诊断和手术切除范围的确定有一定的参考价值。
The aim of this study was to analyze and describe the intrapapillary capillary loops (IPCL), which are a feature of early oral neoplastic lesions, using a narrowband imaging (NBI) system. Forty-one patients (26 men, 15 women; mean age, 52.34 years; range, 23-83 years) presenting with non-neoplastic or neoplastic lesions, and normal cases, were examined using the prototype Evis Lucera Spectrum (Olympus Co.). The images were analyzed and an IPCL classification was devised. All normal cases (n = 10) had regularly distributed capillary loops of the same shape (type I). Non-neoplastic lesions (n = 8) had mild changes of the capillary loops (types II and II) and neoplastic lesions (n = 23) were irregularly distributed and had several loop shapes (types III and IV). The microvascular organization of non-neoplastic lesions was notably different from that of neoplastic lesions. A brownish area was found in five cases of early carcinoma. The narrowband imaging system is a potential approach for clinically analyzing microvascular organization and IPCL. It could be useful for diagnosing oral squamous cell carcinoma at an earlier stage and for determining the margin of resection.