Postprandial response of plasma insulin, amylin and acylated ghrelin to various test meals in lean and obese cats
Postprandial response of plasma insulin, amylin and acylated ghrelin to various test meals in lean and obese cats
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DOI：
10.1017/s000711450999359x
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发表时间：
2010-06-14
影响因子：
3.6
通讯作者：
Dumon, Henri J. W.
中科院分区：
文献类型：
--
作者：
Martin, Lucile J. M.;Siliart, Brigitte;Dumon, Henri J. W.
不同组成的饮食促进肥胖的倾向是猫科动物医学的当前主题。比较了不同蛋白质与脂肪比例的三餐对参与控制摄食和糖代谢的激素（胰岛素、酰化生长激素释放肽和胰淀素）的影响。研究了5只瘦型（2只雌性和3只雄性，28.6（so 3.4）%体脂质量（BFM），平均体重（BW）4590 g）和5只肥胖型（2只雌性和3只雄性，37.1（so 4.1）% BFM，平均BW 4670 g）成年猫。只有BFM显着不同的肥胖和瘦猫。在随机交叉设计中，猫被喂食高蛋白（HP）、高脂肪和高碳水化合物饮食。不同饮食喂养的猫之间的食物摄入量没有差异，但肥胖的猫消耗的能量显着更多，表示为每公斤无脂肪质量，比瘦猫。经过6周的适应期后，给予试验餐，并在餐前和餐后0、30、60和100 min采集血样。基线浓度的葡萄糖，胰淀素和酰化ghrelin肥胖猫高于瘦猫，和肥胖猫显示最高的餐后葡萄糖和胰淀素的反应。HP饮食导致餐后胰淀素浓度高于其他饮食，表明氨基酸对β细胞分泌的可能影响。餐后胃饥饿素浓度不受饮食组成的影响。胰岛素、胰淀素和ghrelin分泌之间的关系以及它们在猫的食物摄取和糖代谢中的相关作用需要进一步研究。
The propensity of diets of different composition to promote obesity is a current topic in feline medicine. The effects of three meals with different protein:fat ratios on hormones (insulin, acylated ghrelin and amylin) involved in the control of food intake and glucose metabolism were compared. Five lean (two females and three males, 28.6 (so 3.4) % body fat mass (BFM), mean body weight (BW) 4590 g) and five obese (two females and three males, 37.1 (so 4.1) % BFM, mean BW 4670 g) adult cats were studied. Only BFM differed significantly between obese and lean cats. The cats were fed a high-protein (HP), a high-fat and a high-carbohydrate diet in a randomised cross-over design. Food intake did not differ between cats fed on the different diets, but obese cats consumed significantly more energy, expressed as per kg fat-free mass, than lean cats. After a 6-week adaptation period, a test meal was given and blood samples were collected before and 0, 30, 60 and 100 min after the meal. Baseline concentrations of glucose, amylin and acylated ghrelin were higher in obese cats than in lean cats, and obese cats showed the highest postprandial responses of glucose and amylin. The HP diet led to higher postprandial amylin concentrations than the other diets, indicating a possible effect of amino acids on beta-cell secretion. Postprandial ghrelin concentrations were unaffected by diet composition. The relationship between insulin, amylin and ghrelin secretion and their relevant roles in food intake and glucose metabolism in cats require further study.