Determination of metastable zone width, induction period and primary nucleation kinetics for cooling crystallization of L-asparaginenohydrate
Determination of metastable zone width, induction period and primary nucleation kinetics for cooling crystallization of L-asparaginenohydrate
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DOI：
10.1016/j.jcrysgro.2014.09.027
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发表时间：
2014-12-15
影响因子：
1.8
通讯作者：
Sarkar, Debasis
中科院分区：
文献类型：
--
作者：
Lenka, Maheswata;Sarkar, Debasis
对L-天冬酰胺一水合物无晶种间歇冷却结晶的诱导时间和介稳区宽度进行了系统的研究。在三个不同的温度下，在不同的过饱和比的诱导期进行了测量。感应石灰测量揭示了一个均匀的成核区域在高过饱和度和非均匀的成核区域在低过饱和度。诱导时间数据进行了分析，使用经典的成核理论计算界面能和各种成核参数，如临界核的半径，核的临界自由能，成核速率等。MSZW测量在三个不同的冷却速率和成核动力学参数估计从MSZW数据使用经典的NyvIt理论。(C)2014爱思唯尔有限公司版权所有。
A systematic investigation is carried out to determine the induction time and metastable zone width (MSZW) for unseeded batch cooling crystallization of L-asparagine monohydrate. The induction period was measured at three different temperatures at different supersaturation ratios. The induction Lime measurements reveal a homogeneous nucleation region at high supersaturations and a heterogeneous nucleation region at low supersaturations. The induction time data are analyzed using classical nucleation theory to calculate interfacial energy and various nucleation parameters, such as the radius of critical nucleus, the critical free energy of nucleus, nucleation rate, etc. The MSZW was measured at three different cooling rates and the nucleation kinetic parameters are estimated from MSZW data using classical NyvIt theory. (C) 2014 Elsevier B.V. All rights reserved.