Visuoconstructive performance and regional cerebral glucose metabolism in Alzheimer's disease.
Visuoconstructive performance and regional cerebral glucose metabolism in Alzheimer's disease.
复制标题
阿尔茨海默病的视觉结构表现和局部脑葡萄糖代谢。
DOI：
10.1080/01688639108401088
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发表时间：
1991
影响因子：
2.2
通讯作者：
Friedland,RP
中科院分区：
文献类型：
--
作者：
Ober,BA;Jagust,WJ;Koss,E;Delis,DC;Friedland,RP
阿尔茨海默氏病（AD）患者和老年对照组的图纸进行了评级的一些特定的性能尺度，如注意配置，注意细节，刺激有界性。AD患者表现出显着较差的性能比对照组在大多数绘图量表，和绘图措施的差异受疾病严重程度。通过正电子发射断层扫描（PET，18 FDG）评估AD患者亚组的局部脑葡萄糖代谢（rCMRglc）。rCMRglc与绘图措施（年龄，性别和教育作为控制变量）的偏相关性进行。8项绘图测量中有5项与左右半球枕叶和/或颞顶叶区域的rCMRglc显著相关（p <0.005）。在8项绘画测量指标中，只有一项（注意细节）与额叶和后额叶的rCMRglc显著相关，同样是两个半球。总体痴呆严重程度与任何地区的rCMRglc均无显著相关性。这些发现提示在AD的绘画表现和脑代谢之间的关系中存在后前分化，但没有左右半球分化，这不能用整体痴呆严重程度来解释。讨论了AD和单侧脑损伤患者绘画表现之间的差异，并建议进一步应用评分量表（见附录）。
The drawings of Alzheimer's disease (AD) patients and elderly control subjects were rated on a number of specific performance scales, such as attention to configuration, attention to detail, and stimulus boundedness. AD patients showed significantly poorer performance than controls on most drawing scales, and the drawing measures were differentially affected by disease severity. Regional cerebral glucose metabolism (rCMRglc) was assessed via positron emission tomography (PET, with18FDG) in a subgroup of the AD patients. Partial correlations of rCMRglc with drawing measures (age, sex, and education served as control variables) were conducted. Five out of eight of the drawing measures were significantly correlated (p < .005) with rCMRglc in occipital and/or temporal-parietal regions, for both left and right hemispheres. Only one of the eight drawing measures, attention to detail, was significantly correlated with rCMRglc in both frontal and posterior regions of interest, again for both hemispheres. Overall dementia severity showed no significant correlations with rCMRglc in any of the regions. These findings are suggestive of a posterior-anterior differentiation, but no left-right hemisphere differentiation, in the relationship between drawing performance and cerebral metabolism in AD, which cannot be accounted for by overall dementia severity. Differences between the drawing performance of AD and unilateral brain damaged patients are discussed, and further applications of the rating scales (provided in the Appendix) are suggested.
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DOI：
--
发表时间：
1967
期刊：
影响因子：
--
作者：
R. Lehman;M. Spiegel;M. Mccafferty;E. Dallos;Z. Oberman;M. Herzberg;M. Streifler;S. Lavy;A. Silverstein;S. Stern
通讯作者：
S. Stern
影响因子：
6.9
作者：
V. Moore;M. Wyke
通讯作者：
M. Wyke
右半球在某些非语言智力技能方面占主导地位。
DOI：
--
发表时间：
1962
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
M. Piercy;V. Smyth
通讯作者：
V. Smyth
施工能力受到干扰。
DOI：
--
发表时间：
1970
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
D. Benson;M. Barton
通讯作者：
M. Barton
影响因子：
11
作者：
HANNAY, HJ;VARNEY, NR;BENTON, AL
通讯作者：
BENTON, AL