The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women
The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women
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DOI：
10.1093/infdis/174.5.927
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发表时间：
1996-11-01
影响因子：
6.4
通讯作者：
Galloway, DA
中科院分区：
文献类型：
--
作者：
Carter, JJ;Koutsky, LA;Galloway, DA
为了研究血清抗体反应与人乳头状瘤病毒 16 型 (HPV-16) 感染之间的时间关系，对 325 名大学女性进行了每隔 4 个月一次的检查，每次检查时均完成访谈，获取细胞用于基于聚合酶链反应的检测和巴氏筛查，并获取血清用于 HPV-16 衣壳捕获 ELISA 检测，血清反应性与 HPV-16 DNA 检测和性别数量增加相关合作伙伴，发生 HPV-16 感染的女性中，血清转换的中位时间为 8.3 个月，在 HPV-16 DNA 检测后 16 个月内，93.7% 的流行女性和 67.1% 的偶发感染女性发生了血清转换，血清转换后，HPV-16 DNA 阳性女性在随访期间保持了抗体反应，血清转换的女性是 5.7 倍（95% 置信区间） = 2.4-13.4) 与未发生血清转化的女性相比，更可能出现与 HPV-16 DNA 检测相关的鳞状上皮内病变。
To study the temporal relationship between serum antibody response and human papillomavirus type 16 (HPV-16) infection, a cohort of 325 university women were scheduled for examinations at 4-month intervals, At every examination, interviews were completed, cells were obtained for polymerase chain reaction-based testing and for Pap screening, and serum was obtained for testing with a HPV-16 capsid-capture ELISA, Seroreactivity was associated with detection of HPV-16 DNA and with increased numbers of sex partners, The median time to seroconversion was 8.3 months among women with incident HPV-16 infections, Within 16 months following HPV-16 DNA detection, 93.7% of women with prevalent and 67.1% of women with incident infections seroconverted, After seroconversion, antibody responses were maintained during follow-up among HPV-16 DNA-positive women, Women who seroconverted were 5.7 times (95% confidence interval = 2.4-13.4) more likely to have squamous intraepithelial lesions associated with the detection of HPV-16 DNA than were women who did not seroconvert.