Barrier function of airway tract epithelium.
Barrier function of airway tract epithelium.
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DOI：
10.4161/tisb.24997
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发表时间：
2013-10-01
期刊：
影响因子：
3.1
通讯作者：
Sajjan US
中科院分区：
文献类型：
--
作者：
Ganesan S;Comstock AT;Sajjan US
呼吸道上皮细胞对呼吸道屏障功能有重要作用。黏液纤毛扶梯、调节细胞旁通透性的细胞间顶端连接复合体和呼吸道上皮细胞分泌的抗菌肽是呼吸道屏障功能的三个主要组成部分。这三种成分协同作用，在不引发炎症的情况下清除吸入的病原体、过敏原和颗粒物，并维持组织内环境稳定。因此，屏障功能的一个或多个基本成分的损害可能增加感染的易感性，并促进对环境因素(包括过敏原和病原体)的夸大和持久的先天免疫反应，从而导致慢性炎症。在这里，我们回顾了与慢性呼吸道疾病相关的屏障功能成分的调节。
Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary escalator, intercellular apical junctional complexes which regulate paracellular permeability and antimicrobial peptides secreted by the airway epithelial cells are the three primary components of barrier function of airway tract. These three components act cooperatively to clear inhaled pathogens, allergens and particulate matter without inducing inflammation and maintain tissue homeostasis. Therefore impairment of one or more of these essential components of barrier function may increase susceptibility to infection and promote exaggerated and prolonged innate immune responses to environmental factors including allergens and pathogens resulting in chronic inflammation. Here we review the regulation of components of barrier function with respect to chronic airways diseases.