Novel Anti-Aging Benzoquinone Derivatives from Onosma bracteatum Wall
Novel Anti-Aging Benzoquinone Derivatives from Onosma bracteatum Wall
复制标题
Onosma bracteatum Wall 的新型抗衰老苯醌衍生物
DOI：
10.3390/molecules24071428
复制
发表时间：
2019-04-11
期刊：
影响因子：
4.6
通讯作者：
Qi, Jianhua
中科院分区：
文献类型：
--
作者：
Farooq, Umer;Pan, Yanjun;Qi, Jianhua
The aim of this study was to investigate anti-aging molecules from Onosma bracteatum Wall, a traditional medicinal plant used in the Unani and Ayurvedic systems of medicine. During bioassay-guided isolation, two known benzoquinones, allomicrophyllone (1) and ehretiquinone (2) along with three novel benzoquinones designated as ehretiquinones B-D (3-5) were isolated from O. bracteatum. Their structures were characterized by spectroscopic analysis through 1D and 2D NMR, by MS spectroscopic analysis and comparing with those reported in the literatures. The anti-aging potential of the isolated benzoquinones was evaluated through a yeast lifespan assay, and the results indicated that 1, 2, 4 and 5 significantly extended the replicative lifespan of K6001 yeast, indicating that these benzoquinones obtained from O. brateatum have the ability to be employed as a potential therapeutic agent against age-related diseases.
