Genetic Risk Factors of Bronchopulmonary Dysplasia
Genetic Risk Factors of Bronchopulmonary Dysplasia
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DOI：
10.1203/pdr.0b013e318184edeb
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发表时间：
2008-12-01
影响因子：
3.6
通讯作者：
Pietrzyk, Jacek Jozef
中科院分区：
文献类型：
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作者：
Kwinta, Przemko;Bik-Multanowski, Miroslaw;Pietrzyk, Jacek Jozef
本研究旨在探讨支气管肺发育不良(BPD)与血管内皮生长因子(VEGF)、转化生长因子(TGF-β1)、胰岛素样生长因子(IGF-1)和5，10-亚甲基四氢叶酸还原酶(MTHFR)基因多态性的关系。对181名平均胎龄为28wk的新生儿进行了前瞻性评估。对转化生长因子-β1-800G>；A-509C>；T、10T>；C、25G>；C、血管内皮生长因子-460T>；C和405G>；C及MTHFR 677C>；T等位基因进行分子分析，计算IGF-1基因启动子区域CA重复序列的数目。各组中所有的转化生长因子-β1、胰岛素样生长因子-1和亚甲基四氢叶酸还原酶基因的多态频率以及血管内皮生长因子405G和C多态的频率都是相似的。BPD组中携带-460TT和-460CT基因型的新生儿明显高于无BPD组。多变量分析显示，携带T等位基因使BPD的风险增加9%(95%CI：2-14%)，高于为特定胎龄确定的基线风险。氧疗时间长短，还有性生活。基于我们的单中心数据，我们认为VEGF-460T和GT；C基因多态性可能影响BPD的风险。(儿科：682-688,2008)
The aim of the study was to assess the association between bronchopulmonary dysplasia (BPD) and polymorphisms of genes coding for vascular endothelial growth factor (VEGF), transforming growth factor (TGF-beta 1), insulin-like growth factor (IGF-1), and 5,10-methylenetetrahydrofolate reductase (MTHFR). A sample of 181 newborns with mean gestational age of 28 wk was prospectively evaluated. Molecular analysis of TGF-beta 1 -800G>A. -509C>T, 10T>C, 25G>C, VEGF -460T>C and 405G>C and MTHFR 677C>T polymorphisms were performed and the number of CA repeats in the promoter region of IGF-1 gene was assessed. The frequency of all TGF-beta 1, IGF-1, and MTHFR polymorphisms, as well as the frequency of VEGF 405G>C polymorphism was similar in all groups. The newborns with -460TT and -460CT genotypes were significantly overrepresented in the BPD groups compared with the no BPD group. Multivariate analysis revealed that carrying T allele increased the risk of BPD by 9% (95%CI: 2-14%) above the baseline risk established for given gestational age. length of oxygen therapy, and sex. Based on our data from a single center, we propose that VEGF -460T>C polymorphism may influence the risk of BPD. (Pediatr Res 64: 682-688, 2008)