Heroin overdose
Heroin overdose
复制标题
DOI：
10.1111/add.13516
复制
发表时间：
2016-11-01
期刊：
影响因子：
6
通讯作者：
Darke, Shane
中科院分区：
文献类型：
--
作者：
Darke, Shane
背景和aimsThis叙事审查的目的是提供一个简短的历史发展的海洛因过量领域的讨论选择的主要经典'从后半部分的20世纪。方法选取1972年、1977年、1983年、1984年和1999年具有里程碑意义的论文。结果早期的工作结果表明，后来的研究是证明。这些论点包括：过量用药主要发生在耐受性较强的老年使用者中，大多数过量用药的死亡涉及吗啡浓度较低，大多数过量用药涉及多种药物，药物纯度对过量用药率只有适度的影响，海洛因给药后立即死亡的情况很少。从20世纪70年代，80年代和90年代的海洛因过量的里程碑式的研究奠定了基础，随后过量的研究，主要是通过确定过量的情况下，风险因素，生存时间和行为在过量事件的主要人口统计学特征。
Background and aimsThis narrative review aims to provide a brief history of the development of the heroin overdose field by discussing a selection of major classics' from the latter part of the 20th century. MethodsPapers considered landmarks were selected from 1972, 1977, 1983, 1984 and 1999. ResultsFindings of earlier works suggest much of what later research was to demonstrate. These include arguing that overdoses occurred primarily among tolerant older users, that most overdose' deaths involved low morphine concentrations, that most overdoses involve polypharmacy, that drug purity has only a moderate influence on overdose rates and that instant death following heroin administration is rare. ConclusionsLandmark studies of heroin overdose from the 1970s, 1980s and 1990s laid the foundations for subsequent overdose research, mainly by identifying the major demographic characteristics of overdose cases, risk factors, survival times and behaviours at overdose events.