Childhood lymphosarcoma in St. Louis, Missouri, clinically and histologically resembling Burkitt's tumor
Childhood lymphosarcoma in St. Louis, Missouri, clinically and histologically resembling Burkitt's tumor
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密苏里州圣路易斯的儿童淋巴肉瘤，临床和组织学类似于伯基特肿瘤
作者：
R. Dorfman
最近，A O 'Conor、Gluckman、14 Wright 279 29和Harris 15指出，美国儿童淋巴肉瘤病例与非洲儿童恶性淋巴瘤（伯基特瘤）有惊人的相似之处。3 -6 O' Conor 20说，他看到了几个这样病例的组织学材料。Gluckmanl 4坚持认为，在纽约的纪念医院，病例已经用颌骨肿瘤的照片记录下来。他还提到了Brown和O 'Keefe在1928年的一个具体病例报告，涉及一名16岁的圣路易斯女孩，她患有“卵巢肉瘤，伴有不寻常的口腔转移”。他认为，“对这一案件的详细描述无疑与中非的情况相同”。27岁的Wright检查了组织学切片，认为这是发生在美国的伯基特肿瘤的一个例子，这引起了关于伯基特肿瘤是否是一种独特的疾病实体的争议，其表现不同于所谓的儿童常规淋巴肉瘤。布朗和奥基夫的病例已被全面审查，并成为密苏里州圣路易斯市华盛顿大学医学院临床病理会议的主题。患者的肿瘤累及颌骨的所有4个象限、卵巢和乳房。对这些部位的原始活检切片进行显微镜检查，发现伯基特肿瘤的“starrysky”组织学表现（图1）。由D博士检查重复切片。H.乌干达坎帕拉Makerere大学医学院的Wright博士同意这一意见。这刺激了对更多可能病例的研究。一项调查是在
TTENTION RECENTLY HAS BEEN DRAWN BY A O’Conor,20 Gluckman,l4 Wright279 29 and Harris15 to cases of lymphosarcoma in children in the U.S.A. which bear striking similarities to the malignant lymphoma of children in Africa (Burkitt’s tumor).3-6 O’Conor20 states that he has seen histologic material on several such cases. Gluckmanl4 maintains that cases have been recorded with photographs of the jaw tumors at the Memorial Hospital, New York. He also refers to a specific case report by Brown and O’Keefe2 in 1928, concerning a 16-year-old St. Louis girl who had “sarcoma of the ovary with unusual oral metastases.” He believes that “the very detailed description of this case leaves no doubt that it is identical with those described in Central Africa.” Wright,27 who has examined the histological sections, considers this case an example of Burkitt’s tumor occurring in the U.S.A. This has aroused a controversy as to whether Burkitt’s tumor is a distinct disease entity, differing in its manifestations from so-called conventional lymphosarcoma in children. Brown and O’Keefe’s case has been reviewed fully and was the subject of a clinico-pathologic conference17 at Washington University School of Medicine, St. Louis, Missouri. The patient had tumors involving all 4 quadrants of the jaws, both ovaries and the breasts. Microscopic examination of the original biopsy sections from these sites revealed the “starrysky” histological appearance (Fig. 1) characteristic of Burkitt’s tumor. Duplicate sections were examined by Dr. D. H. Wright, Makerere University College Medical School, Kampala, Uganda, who concurred with this opinion. This stimulated a search for further possible cases. A survey was carried out of the