Synergistic effects of loxoprofen and glycine on the micturition reflex in conscious rats.
Synergistic effects of loxoprofen and glycine on the micturition reflex in conscious rats.
复制标题
洛索洛芬和甘氨酸对清醒大鼠排尿反射的协同作用。
DOI：
10.2220/biomedres.35.17
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
M. Kawatani
中科院分区：
文献类型：
--
作者：
Y. Fukiya;M. Yoshizumi;Mikako Saito;K. Matsumoto;Toshie Nimura;M. Kawatani
我们研究了环氧合酶抑制剂洛索洛芬和主要抑制性神经递质甘氨酸对清醒大鼠排尿反射的抑制作用，并假设这些药物会协同作用抑制排尿。使用代谢笼评估排尿行为。口服洛索洛芬可降低排尿频率，仅高剂量（10 mg/kg）可显著降低排尿量。用膀胱测压法测定清醒大鼠的膀胱收缩间期（ICI），洛索洛芬（0.1 ~ 3 mg/kg）和甘氨酸（30和100 mg/kg）均呈剂量依赖性延长，但对最大排尿压（MVP）无明显影响。洛索洛芬（3 mg/kg）和甘氨酸（100 mg/kg）的组合比单独使用任何一种药物都更强烈地延长ICI。洛索洛芬（0.1 mg/kg）和甘氨酸（30 mg/kg）的最低剂量对ICI或MVP均无影响，但其联合给药导致ICI显著增加。这些结果表明，洛索洛芬和甘氨酸的联合给药对排尿反射产生协同抑制作用。
We examined the inhibitory effects of loxoprofen, a cyclooxygenase inhibitor, and glycine, a major inhibitory neurotransmitter, on the micturition reflex in conscious rats and hypothesized that these drugs would interact synergistically to inhibit micturition. Voiding behaviors were assessed using a metabolic cage. Oral loxoprofen decreased the urinary frequency, and only a high dose(10 mg/kg) significantly reduced the voided volume. With cystometry, intravenous loxoprofen(0.1-3 mg/kg) and glycine (30 and 100 mg/kg) prolonged the intercontraction intervals (ICI) in adose-dependent manner, but did not change the maximum voiding pressure (MVP) in conscious rats. The combination of loxoprofen (3 mg/kg) and glycine (100 mg/kg) strongly prolonged the ICI more than with either drug alone. The lowest dose of loxoprofen (0.1 mg/kg) and glycine(30 mg/kg) did not affect either the ICI or the MVP, but their combination resulted in a significant increase in the ICI. These results suggest that the combined administration of loxoprofen and glycine produced a synergistic inhibitory effect on the micturition reflex.
影响因子：
5
作者：
M. Yoshiyama;J. Roppolo;W. C. Groat
通讯作者：
M. Yoshiyama;J. Roppolo;W. C. Groat