High prevalence of smoking among patients with suspected tuberculosis in South Africa.
High prevalence of smoking among patients with suspected tuberculosis in South Africa.
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DOI：
10.1183/09031936.00137710
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发表时间：
2011-07
期刊：
影响因子：
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通讯作者：
Dheda K
中科院分区：
文献类型：
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作者：
Brunet L;Pai M;Davids V;Ling D;Paradis G;Lenders L;Meldau R;van Zyl Smit R;Calligaro G;Allwood B;Dawson R;Dheda K
越来越多的证据表明吸烟是结核病 (TB) 的一个重要危险因素。没有数据验证结核病患者自我报告吸烟的准确性，并且有关高负担环境中结核病患者吸烟流行率的数据也有限。我们对南非开普敦的 500 名疑似结核病患者进行了横断面分析。所有人都接受了全面的诊断测试。他们自我报告的吸烟状况的准确性是根据血清可替宁水平来确定的。在该研究纳入的 424 名患者中，活动性和潜伏性结核感染 (LTBI) 患者中分别有 56% 和 60% 是当前吸烟者。使用血浆可替宁作为参考标准，自我报告吸烟的敏感性为89%。吸烟与活动性结核病或潜伏性结核感染之间没有发现统计学上显着的关联。在开普敦，疑似和确诊结核病患者的吸烟率远高于南非普通人群。自我报告是吸烟状况的准确衡量标准。这些结果表明需要积极地将戒烟计划纳入南非的结核病服务中。
There is growing evidence that tobacco smoking is an important risk factor for tuberculosis (TB). There are no data validating the accuracy of self-reported smoking in TB patients and limited data about the prevalence of smoking in TB patients from high-burden settings. We performed a cross-sectional analysis of 500 patients with suspected TB in Cape Town, South Africa. All underwent comprehensive diagnostic testing. The accuracy of their self-reported smoking status was determined against serum cotinine levels. Of the 424 patients included in the study, 56 and 60% of those with active and latent TB infection (LTBI), respectively, were current smokers. Using plasma cotinine as a reference standard, the sensitivity of self-reported smoking was 89%. No statistically significant association could be found between smoking and active TB or LTBI. In Cape Town, the prevalence of smoking among patients with suspected and confirmed TB was much higher than in the general South African population. Self-reporting is an accurate measure of smoking status. These results suggest the need to actively incorporate tobacco cessation programmes into TB services in South Africa.