Are modifications of melatonin circadian rhythm in the middle years of life related to habitual patterns of light exposure?
Are modifications of melatonin circadian rhythm in the middle years of life related to habitual patterns of light exposure?
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DOI：
10.1177/0748730405280248
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发表时间：
2005-10-01
影响因子：
3.5
通讯作者：
Carrier, J
中科院分区：
文献类型：
--
作者：
Kawinska, A;Dumont, M;Carrier, J
与年龄相关的生物钟信号变化的机制尚未确定。作者试图确定中年褪黑激素昼夜节律的相位提前是否与习惯性光照的不同模式有关。41名年龄在22岁至58岁之间的健康受试者进行了研究。通过腕部监测器测量习惯性光暴露7天。参与者进行了25小时的恒定常规。每隔30 min提供唾液样本，并通过放射免疫测定法测定褪黑素浓度以评估唾液昏暗光褪黑素起效（S-DLMO 1.3）。年龄与早期S-DLMO相关1.3。年龄的增加与在不同光照强度下的时间无关。然而，它与夜间（0200-0400，0600-0700和2300-2400 h之间）的光照百分比较低以及早晨（0800-1100 h之间）的光照百分比较高相关。较早的S-DLMO（1.3）与夜间（2200-0000、0000-0100和0200-0300 h之间）以及下午（1500-1600 h之间）的较低光照百分比以及早晨（0800-1100 h之间）的较高光照百分比相关。在控制年龄影响的情况下，S-DLMO 1.3与光照百分比之间无显著相关性。然而，年龄的增加与早期S-DLMO 1.3相关，而与光暴露模式无关。较早的习惯性醒来时间解释了老年受试者较早的光照模式。习惯觉醒时间和年龄对S-DLMO的预测均有贡献。结果表明，在中年的生活节奏的阶段提前。尽管习惯性光暴露模式的明显变化与衰老和S-DLMO 1.3的变化相关，但它不能完全解释褪黑激素昼夜节律相位的年龄相关性进展。
The mechanisms underlying age-related changes in the signal from the biological clock have yet to be determined. The authors sought to determine if the phase advance of circadian melatonin rhythm during the middle years of life is related to different patterns of habitual light exposure. Forty-one healthy subjects between the ages of 22 and 58 y were studied. Habitual light exposure was measured by a wrist monitor for 7 days. Participants underwent a 25-h constant routine. They provided saliva samples every 30 min, and melatonin concentration was determined by radioimmunoassay to assess salivary dim light melatonin onset (S-DLMO1.3). Aging was associated with earlier S-DLMO1.3. Increasing age was not related to the time spent at different light intensities. However, it was associated with lower percentage of light exposure during the night (between 0200-0400, 0600-0700, and 2300-2400 h) and with higher percentage of light exposure in the morning (between 0800-1100 h). Earlier S-DLMO,(1.3) was associated with lower percentage of light exposure early on in the night (between 2200-0000, 0000-0100, and 0200-0300 h) as well as in the afternoon (between 1500-1600 h) and with higher percentage of light exposure in the morning (between 0800-1100 h). When the effects of age were controlled, there was no significant relationship between S-DLMO1.3 and percentages of light exposure. Yet increasing age was associated with earlier S-DLMO1.3 regardless of light exposure patterns. Earlier habitual wake time explained the earlier light exposure patterns of older subjects. Both habitual wake time and age contributed to the prediction of S-DLMO1.3. The results suggest a phase advance of circadian rhythms in the middle years of life. Whereas a clear change in habitual light exposure patterns was associated with aging and with shifts in S-DLMO1.3, it did not explain entirely the age-related advance of melatonin circadian phase.