Nitric oxide function and signalling in plant disease resistance
Nitric oxide function and signalling in plant disease resistance
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DOI：
10.1093/jxb/erm244
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发表时间：
2008-02-01
影响因子：
6.9
通讯作者：
Loake, Gary J.
中科院分区：
文献类型：
--
作者：
Hong, Jeum Kyu;Yun, Byung-Wook;Loake, Gary J.
一氧化氮（NO）是为数不多的气体信号分子之一。它作为内皮源性舒张因子（EDRF）的发现彻底改变了以前被认为是有毒分子的NO和同源活性氮中间体的看法。NO是植物中一种重要的信号分子，它参与了植物生长、发育和环境相互作用的多种细胞活动。其中突出的是其在植物过敏性细胞死亡和抗病性中的功能。虽然已经提出了许多NO生物合成的来源，但NO生产的稳健和生物学相关途径在很大程度上仍有待确定。阐述细胞死亡过程中不相容的植物病原体相互作用NO功能与活性氧中间体的组合。此外，NO已被证明可以调节后半胱氨酸天冬氨酸蛋白酶的活性，后半胱氨酸天冬氨酸蛋白酶是进化上保守的蛋白酶，可能与病原体触发的细胞死亡密切相关。NO还被认为通过S-亚硝基化调节水杨酸（SA）信号传导途径的多个节点而在植物抗病性的多种模式中起作用。这些发现强调了NO在植物-病原体相互作用中的关键作用。
Nitric oxide (NO) is one of only a handful of gaseous signalling molecules. Its discovery as the endothelium-derived relaxing factor (EDRF) by Ignarro revolutionized how NO and cognate reactive nitrogen intermediates, which were previously considered to be toxic molecules, are viewed. NO is now emerging as a key signalling molecule in plants, where it orchestrates a plethora of cellular activities associated with growth, development, and environmental interactions. Prominent among these is its function in plant hypersensitive cell death and disease resistance. While a number of sources for NO biosynthesis have been proposed, robust and biologically relevant routes for NO production largely remain to be defined. To elaborate cell death during an incompatible plant-pathogen interaction NO functions in combination with reactive oxygen intermediates. Furthermore, NO has been shown to regulate the activity of metacaspases, evolutionary conserved proteases that may be intimately associated with pathogen-triggered cell death. NO is also thought to function in multiple modes of plant disease resistance by regulating, through S-nitrosylation, multiple nodes of the salicylic acid (SA) signalling pathway. These findings underscore the key role of NO in plant-pathogen interactions.