TWO-DIMENSIONAL CONTRAST ECHOCARDIOGRAPHY .1. INVITRO DEVELOPMENT AND QUANTITATIVE-ANALYSIS OF ECHO CONTRAST AGENTS
TWO-DIMENSIONAL CONTRAST ECHOCARDIOGRAPHY .1. INVITRO DEVELOPMENT AND QUANTITATIVE-ANALYSIS OF ECHO CONTRAST AGENTS
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DOI：
10.1016/s0735-1097(84)80424-6
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发表时间：
1984-01-01
影响因子：
24
通讯作者：
CORDAY, E
中科院分区：
文献类型：
--
作者：
FEINSTEIN, SB;TENCATE, FJ;CORDAY, E
为了便于超声造影剂通过微循环和心肌灌注的超声心动图研究，利用超声能量（超声）制备的造影剂相对均匀、稳定、体积小（< 10 .mu）。悬浮在液体溶液中的气体微泡。通过光学显微镜验证了微泡的大小和持久性，并采用体外系统对不同造影剂的峰值回波幅度和回声持久性进行了比较评估。本研究表明，虽然各种手摇和超声造影剂的回波强度都令人满意，但超声造影剂明显优于手摇造影剂，因为超声造影剂产生的微泡更小、更均匀、更稳定，适合于心肌超声造影剂。在所检测的造影剂中，山梨糖醇（70%）和葡萄糖（70%）的超声溶液似乎具有特殊的潜力，因为微泡(6。2和8，+-。3 .mu。分别)和它们的体外持久性延长。超声产生标准化、小而稳定的微泡，应有利于造影剂通过毛细血管床的生理通道，并允许在右侧、主动脉根、冠状窦或冠状动脉内注射造影剂时对左心肌进行二维成像。
To facilitate the passage of echo contrast agents through the microcirculation and the echocardiographic study of myocardial perfusion, ultrasonic energy (sonication) was employed to produce contrast agents consisting of relatively uniform, stable and small (< 10 .mu. diameter) gaseous microbubbles suspended in liquid solutions. The size and persistence of the microbubbles were verified by light microscopy and an in vitro system was employed for comparative assessment of peak echo amplitude and echo persistence characteristics of various contrast agents. The study indicated that although a variety of hand-agitated and sonicated contrast agents provided satisfactory echo intensities, sonication was clearly superior to the hand-agitation method, because sonication produced smaller, more uniform and more stable microbubbles that could be suitable for myocardial contrast echocardiography. Of the contrast agents examined, sonicated solutions of sorbitol (70%) and dextrose (70%) appeared to have particular potential because of the small sizes of the microbubbles (6 .+-. 2 and 8 .+-. 3 .mu., respectively) and their prolonged in vitro persistence. The use of sonication of produce standardized, small and stable microbubbles should facilitate physiologic passage of the contrast agent through the capillary beds and allow 2-dimensional imaging of the left heart myocardium during right-sided, aortic root, coronary sinus or intracoronary contrast injections.