Photon-counting digital mammography: evaluation of performance under clinically relevant conditions.

Photon-counting digital mammography: evaluation of performance under clinically relevant conditions.
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光子计数数字乳房X线摄影:临床相关条件下的性能评估。

DOI:
10.1016/j.acra.2012.05.007
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发表时间:
2012
期刊:
影响因子:
4.8
通讯作者:
Karellas,Andrew
Karellas,Andrew
中科院分区:
医学3区
文献类型:
--
作者:
Karellas,Andrew

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In this issue, Cole et al (1) report on the performance of a photon-counting digital mammography system (PCM) compared to a more established conventional full-field digital mammography (FFDM) system under clinically relevant image interpretation conditions involving 16 radiologists. The study was aimed at demonstrating noninferiority of PCM compared to the FFDM reference standard. In this study, the performance of two distinctly different digital mammography systems was evaluated using an enriched population that included 133 women, 67 of whom had a recent conventional FFDM procedure and prospective PCM in this presumed normal group, and 66 women with actionable findings from mammography who had prospective PCM and FFDM. This group yielded 49 cancers and 17 benign findings.The strategy of using a cancer-enriched population in such noninferiority studies that assess one imaging technology versus another that serves as the reference standard provides a powerful and efficient tool for the assessment of the performance of the candidate modality. The analysis of performance in this study included relative sensitivity, probability of malignancy assessment, specificity and lesion level analysis, and radiation dose.
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