Towards quantitative magnetic particle imaging: A comparison with magnetic particle spectroscopy
Towards quantitative magnetic particle imaging: A comparison with magnetic particle spectroscopy
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DOI：
10.1063/1.5006391
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发表时间：
2018-05-01
期刊：
影响因子：
1.6
通讯作者：
Wiekhorst, Frank
中科院分区：
文献类型：
--
作者：
Paysen, Hendrik;Wells, James;Wiekhorst, Frank
磁颗粒成像（MPI）是一种定量成像技术，在生物医学领域具有广泛的应用前景。在这里，我们定量地研究了MPI测量期间获得的原始数据。我们提出了一种校准MPI扫描仪输出的方法，使用磁粒子光谱仪（MPS）的测量来产生磁矩单位的数据。在具有一维激励场的简化MPI模式下验证了校准技术。利用MPS和MPI的校准结果，我们确定并比较了每个系统的检出限。MPS的检测限为5.10(-12)Am-2， MPI的检测限为3.6.10(-10)Am-2。最后，对三维激励下的标准MPI测量所包含的定量信息进行了分析，并与之前的结果进行了比较，结果表明，在一维激励下，奇次谐波的信号幅度有所下降。我们对所有获得的结果提出物理解释；并讨论了改进MPI技术可能带来的好处。(C) 2017作者：
Magnetic Particle Imaging (MPI) is a quantitative imaging modality with promising features for several biomedical applications. Here, we study quantitatively the raw data obtained during MPI measurements. We present a method for the calibration of the MPI scanner output using measurements from a magnetic particle spectrometer (MPS) to yield data in units of magnetic moments. The calibration technique is validated in a simplified MPI mode with a 1D excitation field. Using the calibrated results from MPS and MPI, we determine and compare the detection limits for each system. The detection limits were found to be 5.10(-12) Am-2 for MPS and 3.6.10(-10) Am-2 for MPI. Finally, the quantitative information contained in a standard MPI measurement with a 3D excitation is analyzed and compared to the previous results, showing a decrease in signal amplitudes of the odd harmonics related to the case of 1D excitation. We propose physical explanations for all acquired results; and discuss the possible benefits for the improvement of MPI technology. (C) 2017 Author(s).