Rapid eye movement sleep in relation to overweight in children and adolescents
Rapid eye movement sleep in relation to overweight in children and adolescents
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DOI：
10.1001/archpsyc.65.8.924
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发表时间：
2008-08-01
影响因子：
--
通讯作者：
Dahl, Ronald E.
中科院分区：
文献类型：
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作者：
Liu, Xianchen;Forbes, Erika E.;Dahl, Ronald E.
内容：睡眠时间短与肥胖有关，但很少有研究探讨肥胖与睡眠的特定生理阶段之间的关系。目的：研究儿童和青少年的特定睡眠阶段，包括快速眼动（REM）睡眠和非REM睡眠的第1阶段至第4阶段，与超重的关系。设计、设置和参与者：共有335名儿童和青少年（55.2%男性;年龄7- 17岁）连续3晚接受标准多导睡眠图和体重及身高评估，作为内化障碍发展研究的一部分。（抑郁和焦虑）。主要结果测量：体重指数（计算方法为体重（千克）除以身高（米）的平方）z评分和体重状况根据年龄和性别的体重指数百分位数（正常、有超重风险、超重）。体重指数z评分与总睡眠时间显著相关（β =-0.174）、睡眠效率（β =-0.027）和REM密度（β =-0.256）。与正常体重儿童相比，超重儿童睡眠时间约少22分钟，睡眠效率较低，快速眼动睡眠时间较短，快速眼动活动和密度较低，到第一个快速眼动期的潜伏期较长。在调整人口统计学、青春期状态和精神病诊断后，总睡眠时间减少1小时与超重几率增加约2倍相关（比值比= 1.85），REM睡眠时间减少1小时，（比值比= 2.91），REM密度和活动低于中位数的超重几率增加2倍结论：我们的研究结果证实了以前的流行病学观察，即睡眠时间短与儿童和青少年超重有关。睡眠时间短和超重之间联系的一个核心方面可能归因于REM睡眠减少。需要进一步的研究来调查可能的机制，这些机制支持REM睡眠减少与可能导致肥胖的内分泌和代谢变化之间的联系。
Context: Short sleep duration is associated with obesity, but few studies have examined the relationship between obesity and specific physiological stages of sleep.Objective: To examine specific sleep stages, including rapid eye movement ( REM) sleep and stages 1 through 4 of non- REM sleep, in relation to overweight in children and adolescents.Design, Setting, and Participants: A total of 335 children and adolescents ( 55.2% male; aged 7- 17 years) underwent 3 consecutive nights of standard polysomnography and weight and height assessments as part of a study on the development of internalizing disorders ( depression and anxiety).Main Outcome Measures: Body mass index ( calculated as weight in kilograms divided by height in meters squared) z score and weight status ( normal, at risk for overweight, overweight) according to the body mass index percentile for age and sex.Results: The body mass index z score was significantly related to total sleep time (beta=- 0.174), sleep efficiency (beta=- 0.027), and REM density (beta=- 0.256). Compared with normal- weight children, overweight children slept about 22 minutes less and had lower sleep efficiency, shorter REM sleep, lower REM activity and density, and longer latency to the first REM period. After adjustment for demographics, pubertal status, and psychiatric diagnosis, 1 hour less of total sleep was associated with approximately 2- fold increased odds of overweight ( odds ratio= 1.85), 1 hour less of REM sleep was associated with about 3- fold increased odds ( odds ratio= 2.91), and REM density and activity below the median increased the odds of overweight by 2- fold ( odds ratio= 2.18) and 3- fold ( odds ratio= 3.32), respectively.Conclusions: Our results confirm previous epidemiological observations that short sleep time is associated with overweight in children and adolescents. A core aspect of the association between short sleep duration and overweight may be attributed to reduced REM sleep. Further studies are needed to investigate possible mechanisms underpinning the association between diminished REMsleep and endocrine and metabolic changes that may contribute to obesity.