Anodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex enhances emotion recognition in depressed patients and controls
Anodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex enhances emotion recognition in depressed patients and controls
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DOI：
10.1080/13803395.2016.1230595
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发表时间：
2017-05-01
影响因子：
2.2
通讯作者：
Glennon, Mark
中科院分区：
文献类型：
--
作者：
Brennan, Sean;McLoughlin, Declan M.;Glennon, Mark
简介：经颅直流电刺激（tDCS）可以增强一系列神经心理学功能，但其在解决与抑郁症相关的临床显著情绪识别缺陷方面的疗效在很大程度上未经测试。方法：一项随机交叉安慰剂对照研究被用来调查tDCS在左背外侧前额叶皮层（L-DLPFC）的影响范围内的神经心理学变量与抑郁症以及相关的大脑区域的神经活动。在假手术和阳极（1.5mA）刺激期间，对临床组（n=17）和对照组（n=20）进行了一系列计算机测试。结果如下：阳极tDCS导致整体情绪识别的显著主效应（p=.02），对照组有显著改善（p=.04）。在临床组中，对厌恶的认识显著更高（p= 0.01）。在阳极刺激期间，临床组（p= 0.04）的愤怒识别率显著提高。在不同表达水平下，六种情绪中每一种的组间差异发现，在40%的阳极刺激期间，临床组的快乐识别显着改善（p= 0.01）。临床组在阳极刺激期间80%的愤怒识别率显著提高（p= 0.02）。这些改善是在阳极刺激期间精神速度或线索制作能力没有任何变化的情况下观察到的。临床组在阳极刺激期间工作记忆显著改善，但对照组没有（p= 0.03）。结论：本研究的初步结果表明，tDCS可以有一系列的神经心理变量的神经调节作用。然而，很明显，对tDCS的反应有很大的差异，个体差异和不同的测试和刺激方法对最终结果有显著影响。尽管如此，tDCS仍然是未来神经心理学研究的一个有前途的工具。
Introduction: Transcranial direct current stimulation (tDCS) can enhance a range of neuropsychological functions but its efficacy in addressing clinically significant emotion recognition deficits associated with depression is largely untested. Method: A randomized crossover placebo controlled study was used to investigate the effects of tDCS over the left dorsolateral prefrontal cortex (L-DLPFC) on a range of neuropsychological variables associated with depression as well as neural activity in the associated brain region. A series of computerized tests was administered to clinical (n=17) and control groups (n=20) during sham and anodal (1.5mA) stimulation. Results: Anodal tDCS led to a significant main effect for overall emotion recognition (p=.02), with a significant improvement in the control group (p=.04). Recognition of disgust was significantly greater in the clinical group (p=.01). Recognition of anger was significantly improved for the clinical group (p=.04) during anodal stimulation. Differences between groups for each of the six emotions at varying levels of expression found that at 40% during anodal stimulation, happy recognition significantly improved for the clinical group (p=.01). Anger recognition at 80% during anodal stimulation significantly improved for the clinical group (p=.02). These improvements were observed in the absence of any change in psychomotor speed or trail making ability during anodal stimulation. Working memory significantly improved during anodal stimulation for the clinical group but not for controls (p=.03). Conclusions: The tentative findings of this study indicate that tDCS can have a neuromodulatory effect on a range of neuropsychological variables. However, it is clear that there was a wide variation in responses to tDCS and that individual difference and different approaches to testing and stimulation have a significant impact on final outcomes. Nonetheless, tDCS remains a promising tool for future neuropsychological research.