Meta-Analysis of 89 Structural MRI Studies in Posttraumatic Stress Disorder and Comparison With Major Depressive Disorder.
Meta-Analysis of 89 Structural MRI Studies in Posttraumatic Stress Disorder and Comparison With Major Depressive Disorder.
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DOI：
10.1176/appi.ajp.2018.17111199
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发表时间：
2018-10-01
期刊：
影响因子：
--
通讯作者：
Kempton MJ
中科院分区：
文献类型：
--
作者：
Bromis K;Calem M;Reinders AATS;Williams SCR;Kempton MJ
对创伤后应激障碍（PTSD）的MRI感兴趣区和基于体素的形态测量学（VBM）研究进行全面的荟萃分析。由于患者有高比例的共病抑郁症，另一个目的是将结果与抑郁症MRI研究的荟萃分析进行比较。检索了MEDLINE数据库中1985年至2016年的研究。共有113项研究符合纳入标准，并被纳入在线数据库。其中，66个被选择用于感兴趣区域荟萃分析，13个用于VBM荟萃分析。进行了感兴趣区域的荟萃分析，并与重性抑郁症的荟萃分析进行了比较。在关注区域荟萃分析中，进行了三项子分析，包括有创伤和无创伤的对照组。在感兴趣区域的荟萃分析中，与所有对照组相比，PTSD患者的脑体积、颅内体积以及海马、小脑和前扣带回体积均减少。PTSD患者与非创伤或创伤对照组相比，表现出类似的变化。与非创伤对照组相比，创伤组双侧海马体积较小。对于所有地区，合并效应量（Hedges' g）从-0.84到0.43不等，研究数量从3到41不等。VBM荟萃分析显示，内侧前额叶皮质（包括前扣带回）的体积显著减少。与重性抑郁症患者的感兴趣区域数据相比，PTSD患者的总脑体积减少，两种疾病都与海马体积减少有关。荟萃分析揭示了与创伤后应激障碍和创伤相关的脑结构异常，并表明全球脑容量减少将创伤后应激障碍与重度抑郁症区分开来。
To conduct a comprehensive meta-analysis of MRI region-of-interest and voxel-based morphometry (VBM) studies in posttraumatic stress disorder (PTSD). As patients have high rates of comorbid depression an additional objective was to compare the findings to a meta-analysis of MRI studies in depression. The MEDLINE database was searched for studies from 1985 through 2016. A total of 113 studies met inclusion criteria and were included in an online database. Of these, 66 were selected for the region-of-interest meta-analysis and 13 for the VBM meta-analysis. The region-of-interest meta-analysis was conducted and compared with a meta-analysis of major depressive disorder. Within the region-of-interest meta-analysis, three subanalyses that included control groups with and without trauma were conducted. In the region-of-interest meta-analysis, patients with PTSD compared with all control subjects were found to have reduced brain volume, intracranial volume, and volumes of the hippocampus, insula, and anterior cingulate. PTSD patients compared with nontraumatized or traumatized control subjects showed similar changes. Traumatized compared with nontraumatized control subjects showed smaller volumes of the hippocampus bilaterally. For all regions, pooled effect sizes (Hedges’ g) varied from −0.84 to 0.43, and number of studies from three to 41. The VBM meta-analysis revealed prominent volumetric reductions in the medial prefrontal cortex, including the anterior cingulate. Compared with region-of-interest data from patients with major depressive disorder, those with PTSD had reduced total brain volume, and both disorders were associated with reduced hippocampal volume. The meta-analyses revealed structural brain abnormalities associated with PTSD and trauma and suggest that global brain volume reductions distinguish PTSD from major depression.
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影响因子：
11
作者：
Hibar, D. P.;Westlye, L. T.;van Erp, T. G. M.;Rasmussen, J.;Leonardo, C. D.;Faskowitz, J.;Haukvik, U. K.;Hartberg, C. B.;Doan, N. T.;Agartz, I.;Dale, A. M.;Gruber, O.;Kraemer, B.;Trost, S.;Liberg, B.;Abe, C.;Ekman, C. J.;Ingvar, M.;Landen, M.;Fears, S. C.;Freimer, N. B.;Bearden, C. E.;Sprooten, E.;Glahn, D. C.;Pearlson, G. D.;Emsell, L.;Kenney, J.;Scanlon, C.;McDonald, C.;Cannon, D. M.;Almeida, J.;Versace, A.;Caseras, X.;Lawrence, N. S.;Phillips, M. L.;Dima, D.;Delvecchio, G.;Frangou, S.;Satterthwaite, T. D.;Wolf, D.;Houenou, J.;Henry, C.;Malt, U. F.;Boen, E.;Elvsashagen, T.;Young, A. H.;Lloyd, A. J.;Goodwin, G. M.;Mackay, C. E.;Bourne, C.;Bilderbeck, A.;Abramovic, L.;Boks, M. P.;van Haren, N. E. M.;Ophoff, R. A.;Kahn, R. S.;Bauer, M.;Pfennig, A.;Alda, M.;Hajek, T.;Mwangi, B.;Soares, J. C.;Nickson, T.;Dimitrova, R.;Sussmann, J. E.;Hagenaars, S.;Whalley, H. C.;McIntosh, A. M.;Thompson, P. M.;Andreassen, O. A.
通讯作者：
Andreassen, O. A.
影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
11.3
作者：
Herringa R;Phillips M;Almeida J;Insana S;Germain A
通讯作者：
Germain A
影响因子：
4.3
作者：
Hughes KC;Shin LM
通讯作者：
Shin LM
影响因子：
4.5
作者：
Kempton, Matthew J.;Stahl, Daniel;DeLisi, Lynn E.
通讯作者：
DeLisi, Lynn E.