Osmotic regulation of evaporative water loss and body temperature by intracranial receptors in the heat-stressed cat
Osmotic regulation of evaporative water loss and body temperature by intracranial receptors in the heat-stressed cat
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热应激猫颅内受体对蒸发失水和体温的渗透调节
DOI：
10.1007/bf00657244
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
P. Doris
中科院分区：
文献类型：
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作者：
P. Doris
通过在热应激的水合和脱水猫的脑室内（ICV）输注水（0.034 ml·min−1）来检查颅内室渗透环境改变对体温（Tb）调节的影响。在环境温度 (Ta) 为 38°C 时，在 ICV 输水之前，正常补水的猫的平均 Tb（在下丘脑中测量）为 38.8±0.1°C，平均蒸发失水量 (EWL) 为 1.32±0.18 W·kg−1。 ICV水输注对正常饮水动物中的这些值均没有显着影响（P>0.05，t检验）。在 Ta 38°C 脱水动物中，Tb 和 EWL 均较正常脱水状态显着改变（P<0.001），分别在 39.9±0.2°C 和 0.84±0.09 W·kg−1 下测量。向脱水动物输注水显着改变输注前的Tb和EWL水平，使得Tb下降至39.4±0.2°C (P<0.001)，EWL上升至1.46±0.09 W·kg−1(P<0.001) 在正常水合动物中未观察到ICV水输注对平均血浆加压素水平(pAVP)的影响(输注前pAVP = 1.3±0.2 μU·ml−1，输注后pAVP = 1.3±0.3 μU·ml−1，P<0.05)。然而，脱水动物输注后pAVP显着降低（输注前pAVP = 16.6±1.85 μU·ml−1，输注后pAVP = 10.7±2.3 μU·ml−1，P<0.05）。结果表明，能够对水或水中溶质浓度做出反应的颅内感觉元件可能参与了脱水、热应激动物 EWL 的抑制。
The effect on body temperature (Tb) regulation of alterations in the osmotic milieu of the intracranial compartment has been examined by intracerebroventricular (ICV) infusion of water (0.034 ml·min−1) in heat-stressed hydrated and dehydrated cats. At an ambient temperature (Ta) of 38°C, before ICV water infusion, mean Tb (measured in the hypothalamus) of normally hydrated cats was 38.8±0.1°C and mean evaporative water loss (EWL) was 1.32±0.18 W ·kg−1. ICV water infusion was without significant effect (P>0.05,t-test) on either of these values in normally hydrated animals. In dehydrated animals at Ta 38°C, Tb and EWL were both significantly altered (P<0.001) from the normally hydrated state and were measured at 39.9±0.2°C and 0.84±0.09 W·kg−1respectively. Infusion of water into dehydrated animals significantly altered pre-infusion levels of Tb and EWL so that Tb fell to 39.4±0.2°C (P<0.001) and EWL rose to 1.46±0.09 W·kg−1(P<0.001) No effect of ICV water infusion on mean plasma vasopressin levels (pAVP) was observed in normally hydrated animals (preinfusion pAVP = 1.3±0.2 μU·ml−1, post-infusion pAVP = 1.3±0.3 μU·ml−1,P<0.05). However, a significant reduction in pAVP occurred subsequent to infusion in dehydrated animals (pre-infusion pAVP = 16.6±1.85 μU ·ml−1, post-infusion pAVP = 10.7±2.3 μU·ml−1,P<0.05). The results suggest that intracranial sensory elements capable of responding to the concentration of water, or solutes in water, may be involved in the suppression of EWL in dehydrated, heat-stressed animals.