Investigation of prognostic factors for post-traumatic olfactory dysfunction
Investigation of prognostic factors for post-traumatic olfactory dysfunction
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DOI：
10.1016/j.jcma.2014.11.009
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发表时间：
2015-05-01
影响因子：
3
通讯作者：
Shu, Chih-Hung
中科院分区：
文献类型：
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作者：
Fan, La-Yuan;Kuo, Chin-Lung;Shu, Chih-Hung
背景：创伤后嗅觉功能障碍是常见的，但预后不良。本研究的目的是分析临床特征对创伤后嗅觉功能障碍改善的影响。方法：2007年至2013年，入选创伤后嗅觉功能障碍患者。在第一次和最后一次访视时使用Sniffin' Sticks测试评估嗅觉功能。嗅觉改善被定义为嗅觉状态改变到改善的水平。变量与嗅觉功能障碍的改善，包括年龄，性别，从创伤到第一次访问的时间，最初的嗅觉功能，观察时间和嗅球的完整性的潜在影响，进入Logistic回归analysis.Results：总共，107例患者，平均年龄为40岁。平均随访时间为9.4个月。18名患者（16.8%）的嗅觉功能有所改善。单因素和多因素分析均未发现影响嗅觉恢复的临床因素（均P > 0.05）。结论：外伤后嗅觉功能恢复的预后因素不明显，在一定程度上反映了外伤后嗅觉功能损害的预后不良。本研究的结果提供了有用的信息，临床医生可以使用时，咨询创伤后嗅觉障碍患者的预后，观察的选择，和可能的治疗策略。版权所有（C）2015 Elsevier Taiwan LLC及中华医学会。All rights reserved.
Background: Post-traumatic olfactory dysfunction is common but has a poor prognosis. The purpose of this study was to analyze the effect of clinical features on improvements in post-traumatic olfactory dysfunction.Methods: From 2007 to 2013, patients with post-traumatic olfactory dysfunction were enrolled. Olfactory function was assessed using the Sniffin' Sticks test at the first and final visits. Olfactory improvement was defined as a change in olfactory state to an improved level. Variables with a potential effect on improvements in olfactory dysfunction, including age, sex, time from trauma to first visit, initial olfactory function, observation time, and olfactory bulb integrity, were entered into logistic regression analysis.Results: In total, 107 patients were included, with a mean age of 40 years. The mean follow-up period was 9.4 months. Eighteen patients (16.8%) had improvements with regard to olfactory function. No clinical factors were found to influence olfactory recovery in univariate and multivariate analyses (all p > 0.05). In addition, there were no differences in clinical features between the patients with and without olfactory recovery (all p > 0.05).Conclusion: No significantly favorable prognostic factors for post-traumatic olfactory recovery were identified, reflecting, to some extent, the poor prognosis of post-traumatic olfactory damage. The results of this study provide useful information that clinical physicians can use when counseling patients with post-traumatic olfactory disorder regarding the prognosis, observation choice, and possible treatment strategy. Copyright (C) 2015 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.