Novel synthetic ligands for targeted PET imaging and radiotherapy of copper
Novel synthetic ligands for targeted PET imaging and radiotherapy of copper
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DOI：
10.1016/j.bmcl.2007.09.052
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发表时间：
2007-11-15
影响因子：
2.7
通讯作者：
Sun, Xiankai
中科院分区：
文献类型：
--
作者：
Chong, Hyun-Soon;Mhaske, Santosh;Sun, Xiankai
合成了新型配体NBEA、NBPA、NETA、NE3TA和NE3TA- bn，并对其作为铜放射性同位素的潜在螯合剂用于靶向正电子发射断层扫描（PET）成像或放射治疗进行了评价。用Cu-64对新配体进行放射性标记，并在大鼠血清中评价放射性标记复合物的体外稳定性。血清稳定性结果表明，在测试的配体中，NETA、NE3TA和NE3TA- bn与Cu-64形成稳定的配合物。(C) 2007 Elsevier Ltd.版权所有。
Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA-Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with Cu-64, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA-Bn form stable complexes with Cu-64. (C) 2007 Elsevier Ltd. All rights reserved.