ENDOTHELIAL AND EPITHELIAL-CELL ADHESION MOLECULES
ENDOTHELIAL AND EPITHELIAL-CELL ADHESION MOLECULES
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DOI：
10.1165/ajrcmb/4.3.195
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发表时间：
1991-03-01
影响因子：
6.4
通讯作者：
ALBELDA, SM
中科院分区：
文献类型：
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作者：
ALBELDA, SM
这篇综述将讨论存在于肺内皮细胞和上皮细胞表面的一些特殊的细胞黏附分子。整合素、蛋白多糖和透明质酸受体CD44等分子位于细胞的外膜或基底膜一侧，起细胞-基质受体的作用。钙粘附素、整合素和血小板-内皮细胞黏附分子-1(PECAM-1)存在于相邻内皮细胞和/或上皮细胞的细胞-细胞边界，具有启动或维持细胞-细胞黏附的功能。最后，在炎症过程中，许多可诱导的细胞黏附分子如内皮-白细胞黏附分子-1(ELAM-1)、颗粒相关膜蛋白140(GMP140)、细胞间黏附分子-1(ICAM-1)和血管细胞黏附分子-1(VCAM-1)在这些细胞的管腔表面表达，在白细胞、血小板或肿瘤细胞黏附中起重要的细胞-细胞黏附分子的作用。这些黏附分子可能在维持肺的正常结构和功能以及参与炎症、伤口愈合和恶性疾病的发展和扩散等肺过程中发挥重要作用。
This review will discuss a number of specific cell adhesion molecules present on the surface of endothelial and epithelial cells in the lung. Molecules such as integrins, proteoglycans, and the hyaluronic acid receptor, CD44, are found on the abluminal or basement membrane side of the cell and function as cell-substratum receptors. Cadherins, integrins, and platelet-endothelial cell adhesion molecule-1 (PECAM-1) are present at the cell-cell borders of adjacent endothelial and/or epithelial cells and function to initiate or maintain cell-cell adhesion. Finally, a number of inducible cell adhesion molecules such as endothelial-leukocyte adhesion molecule-1 (ELAM-1), granule-associated membrane protein 140 (GMP140), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) are expressed on the luminal surfaces of these cells during inflammation and function as cell-cell adhesion molecules important in white blood cell, platelet, or tumor cell adhesion. These adhesion molecules likely play important roles in maintaining the normal structure and function of the lung, as well as participating in pulmonary processes such as inflammation, wound healing, and the development and spread of malignant disease.