Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg).
Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg).
复制标题
从小鼠成纤维细胞中分离出编码新型成纤维细胞生长因子受体 (flg) 的 cDNA。
DOI：
10.1016/0006-291x(91)91772-5
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发表时间：
1991
影响因子：
3.1
通讯作者：
Cohen,GH
中科院分区：
文献类型：
--
作者：
Fasel,NJ;Bernard,M;Déglon,N;Rousseaux,M;Eisenberg,RJ;Bron,C;Cohen,GH
Structural definition of the receptors for neurotropic and angiogenic modulators such as fibroblast growth factors and related polypeptides will yield insight into the mechanisms that control early development, embryogenesis, organogenesis, wound repair and neovessel formation. We isolated 3 murine cDNAs encoding different binding domains of these receptors (flg). Comparison of these ectoplasmic portions showed that two of the forms corresponded to previously described murine molecules whereas the third one had a different ectoplasmic portion generated by specific changes in two regions. Interestingly, expression of this third form seems to be restricted in its tissue distribution. Such modifications could influence the ligand specificity of the different receptors and/or their binding affinity.
