Apoptosis, Paraptosis and Autophagy: Death and Survival Pathways Associated with Photodynamic Therapy.
Apoptosis, Paraptosis and Autophagy: Death and Survival Pathways Associated with Photodynamic Therapy.
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DOI：
10.1111/php.12952
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发表时间：
2019-01
影响因子：
3.3
通讯作者：
Kessel D
中科院分区：
文献类型：
--
作者：
Kessel D
光敏剂在特定的亚细胞部位造成光损伤的能力已被证明对表征细胞死亡的途径(S)和选择抗肿瘤效果的最佳靶点很有用。在针对线粒体、溶酶体或内质网的光损伤后，细胞凋亡和自噬都会发生，这种平衡往往是整体疗效的决定因素。溶酶体+线粒体靶点的组合与增强疗效有关。最近，内质网光损伤被发现引起一种主要未被探索的光杀死模式，该模式涉及广泛的细胞质空泡形成，但不代表自噬。这被称为“突触”，似乎是对错误折叠的内质网蛋白的反应。这份报告旨在总结目前与死亡途径有关的知识，并更新与PDT反应有关的信息。图示金丝桃素光敏OVCAR-5细胞照射16小时后可见广泛的细胞质空泡。
The ability of photosensitizing agents to create photodamage at specific sub-cellular sites has proved useful for characterizing pathway(s) to cell death and for selecting optimal targets for anti-tumor efficacy. Both apoptosis and autophagy can occur after photodamage directed at mitochondria, lysosomes or the ER, with the balance often a determinant of overall efficacy. A combination of lysosomal + mitochondrial targets is associated with enhanced efficacy. More recently, ER photodamage was found to evoke a mainly unexplored mode of photokilling that involves extensive cytoplasmic vacuole formation but does not represent autophagy. This has been termed ‘paraptosis’ and appears to be a reaction to the appearance of misfolded ER proteins. This report is designed to summarize current knowledge relating to death pathways and update information relating to paraptosis as a PDT response. Image of paraptosis showing the extensive series of cytoplasmic vacuoles 16 hr after irradiation of OVCAR-5 cells photosensitized with hypericin.
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影响因子：
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