Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli
Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli
复制标题
DOI：
10.1128/aac.00647-07
复制
发表时间：
2007-11-01
影响因子：
4.9
通讯作者：
Zechiedrich, Lynn
中科院分区：
文献类型：
--
作者：
Morgan-Linnell, Sonia K.;Zechiedrich, Lynn
在定义的等基因菌株中，需要至少三个突变，其中两个必须在gyrA中，才能超过氟喹诺酮耐药的CLSI断点。在gyrA和parC中具有双突变的菌株对氟喹诺酮类药物的MIC甚至高于总共具有三个突变的菌株。
In defined, isogenic strains, fit least three mutations, two of which must be in gyrA, were required to exceed the CLSI breakpoint for fluoroquinolone resistance. Strains with double mutations in both gyrA and parC had even higher MICs of fluoroquinolones than strains with totals of three mutations.