Cells react to nanoscale order and symmetry in their surroundings
Cells react to nanoscale order and symmetry in their surroundings
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DOI：
10.1109/tnb.2004.824276
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发表时间：
2004-03-01
影响因子：
3.9
通讯作者：
Aitchison, G
中科院分区：
文献类型：
--
作者：
Curtis, ASG;Gadegaard, N;Aitchison, G
哺乳动物细胞对微结构表面有反应，但关于对纳米结构表面的反应信息很少，而且已经测试的表面在结构上是无序的或随机的。我们现在报告，在聚己内酯或聚甲基丙烯酸甲酯中的纳米颗粒的有序表面阵列(正交或六角形)与较不规则的阵列或平面相比，在降低细胞黏附方面具有显著的效果。凹坑的直径分别为35、75和120 nm，凹坑之间的间距分别为100、200和300 nm。这些细胞似乎能够区分阵列的不同对称性。我们认为，界面作用力可能通过纳米结构来组织，以影响细胞的方式，就像它们影响液晶取向一样。
Mammalian cells react to microstructured surfaces, but there is little information on the reactions to nanostructured surfaces, and such as have been tested are poorly ordered or random in their structure. We now report that ordered surface arrays (orthogonal or hexagonal) of nanopits in polycaprolactone or polymethylmethacrylate have marked effects in reducing cell adhesion compared with less regular arrays or planar surfaces. The pits had diameters of 35, 75, and 120 nm, respectively, with pitch between the pits of 100, 200, and 300 nm, respectively. The cells appear to be able to distinguish between different symmetries of array. We suggest that interfacial forces may be organized by the nanostructures to affect the cells in the same way as they affect liquid crystal orientations.