Neuropsychological outcomes of older breast cancer survivors: cognitive features ten or more years after chemotherapy.
Neuropsychological outcomes of older breast cancer survivors: cognitive features ten or more years after chemotherapy.
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老年乳腺癌幸存者的神经心理学结果：化疗十年或更长时间后的认知特征。
DOI：
10.1176/jnp.2010.22.1.48
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Schultz,SusanK
中科院分区：
文献类型：
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作者：
Yamada,TorriciaH;Denburg,NatalieL;Beglinger,LeighJ;Schultz,SusanK
作者研究了65岁以上接受中年治疗的乳腺癌幸存者对癌症治疗的长期认知影响。30名女性幸存者与30名非癌症、健康的老年人在年龄、教育程度和智商方面进行了匹配。癌症幸存者在执行功能、工作记忆和注意力分散等认知领域的得分显著较低，反映出额叶-皮质下大脑区域的潜在功能障碍。我们的发现表明，在十多年没有患病的乳腺癌幸存者中，以前的癌症治疗可能会进一步增强与年龄相关的大脑变化相关的认知功能障碍。
The authors examined the long-term cognitive implications of cancer treatment among breast cancer survivors over 65 years old who received treatment during midlife. Thirty women survivors were matched with 30 noncancer, healthy older adults in terms of age, education, and IQ. The cancer survivors scored significantly lower in the cognitive domains of executive functioning, working memory, and divided attention, reflecting potential dysfunction in frontal-subcortical brain regions. Our findings suggest that among breast cancer survivors who remain disease-free for more than a decade, the previous cancer treatment may further augment cognitive dysfunction associated with age-related brain changes.