Chronic Diseases among Older Cancer Survivors.
Chronic Diseases among Older Cancer Survivors.
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DOI：
10.1155/2012/206414
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发表时间：
2012
影响因子：
1.8
通讯作者：
Buntinx F
中科院分区：
文献类型：
--
作者：
Deckx L;van den Akker M;Metsemakers J;Knottnerus A;Schellevis F;Buntinx F
Objective.比较老年癌症患者（≥60岁）与老年非癌症患者中既存和后续合并症的发生率。材料和方法。每个癌症患者（n = 3835，平均年龄72岁）与4名非癌症患者在年龄，性别和实践方面相匹配。对所有癌症患者以及乳腺癌、前列腺癌和结直肠癌患者的慢性病发生率进行横断面（诊断时的终生患病率）和纵向（诊断后的发病率）评估。采用logistic和考克斯回归分析比较癌症和非癌症患者。结果癌症和非癌症患者中最常见的既存和偶发慢性疾病的发生率基本相似，但既存COPD除外（OR 1.21，95% CI 1.06-1.37）和随后的癌症诊断后前两年静脉血栓形成（HR 4.20，95% CI 2.74-6.44），与非癌症患者相比，老年癌症患者中的发生率显著更高（P < 0.01）。结论在老年癌症患者中，多发性骨髓瘤的发生率很高。然而，除了COPD和静脉血栓形成，老年癌症患者的慢性病发病率与相同年龄，性别和实践的非癌症患者相似。
Objective. To compare the occurrence of pre-existing and subsequent comorbidity among older cancer patients (≥60 years) with older non-cancer patients. Material and Methods. Each cancer patient (n = 3835, mean age 72) was matched with four non-cancer patients in terms of age, sex, and practice. The occurrence of chronic diseases was assessed cross-sectionally (lifetime prevalence at time of diagnosis) and longitudinally (incidence after diagnosis) for all cancer patients and for breast, prostate, and colorectal cancer patients separately. Cancer and non-cancer patients were compared using logistic and Cox regression analysis. Results. The occurrence of the most common pre-existing and incident chronic diseases was largely similar in cancer and non-cancer patients, except for pre-existing COPD (OR 1.21, 95% CI 1.06–1.37) and subsequent venous thrombosis in the first two years after cancer diagnosis (HR 4.20, 95% CI 2.74–6.44), which were significantly more frequent (P < 0.01) among older cancer compared to non-cancer patients. Conclusion. The frequency of multimorbidity in older cancer patients is high. However, apart from COPD and venous thrombosis, the incidence of chronic diseases in older cancer patients is similar compared to non-cancer patients of the same age, sex, and practice.