Influence of Different Distal Nerve Degeneration Period on Peripheral Nerve Collateral Sprouts Regeneration
Influence of Different Distal Nerve Degeneration Period on Peripheral Nerve Collateral Sprouts Regeneration
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不同远端神经退变期对周围神经侧枝芽再生的影响
DOI：
10.3109/10731199.2010.533127
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发表时间：
2011-08-01
期刊：
影响因子：
--
通讯作者：
Jiang, Baoguo
中科院分区：
文献类型：
--
作者：
Kou, Yuhui;Zhang, Peixun;Jiang, Baoguo
摘要：本文研究了远端神经变性对近端神经残端侧支芽再生的影响。采用延迟交叉缝合吻合术，将新切除的腓总神经和慢性去神经TIB神经残端交叉缝合0 ~ 8周。远端神经退化8周后再生的髓鞘轴突数量显著减少，提示短期去神经支配不影响侧支芽再生，但较长时间的去神经支配会严重减少远端残端侧支芽再生。
Abstract: The effects of the distal nerve degeneration on the regeneration of the collateral sprouts from the proximal nerve stump have been examined. The delayed cross-suture anastomosis technique was used in which the tibial nerve was denervated for 0-8 weeks before cross-suture of the freshly axotomized common peroneal and chronically denervated TIB nerve stumps. There was a remarkable decreasing of the regenerated myelinated axons number after the distal nerve suffered 8 weeks deterioration, suggesting that short-term denervation did not affect the collateral sprouts regeneration but more prolonged denervation profoundly reduced collateral sprouts regenerated in the distal nerve stump.