Maternal serum interleukin-33 and soluble ST2 across early pregnancy, and their association with miscarriage
Maternal serum interleukin-33 and soluble ST2 across early pregnancy, and their association with miscarriage
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DOI：
10.1016/j.jri.2012.06.003
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发表时间：
2012-09-01
影响因子：
3.4
通讯作者：
Tong, Stephen
中科院分区：
文献类型：
--
作者：
Kaitu'u-Lino, Tu'uhevaha J.;Tuohey, Laura;Tong, Stephen
从 1 型免疫偏向到 2 型免疫偏向的转变对于成功着床和妊娠至关重要。 ST2 是 2 型免疫细胞上的一种受体，最近发现 IL-33 是其配体。我们测量了妊娠早期中期可溶性 ST2 (sST2) 和 IL-33 的血清水平，并检查了胎儿可存活但注定流产的女性中水平是否失调。虽然在妊娠前三个月内 sST2 或 IL-3 没有显着变化，但我们发现注定会失败的活孕女性的血清 IL-33 水平失调，并且在妊娠六周时可能还有 sST2 水平失调。 (C) 2012 Elsevier Ireland Ltd. 保留所有权利。
A shift from type 1 to type 2 immune bias is essential for successful implantation and pregnancy. ST2 is a receptor present on type 2 immune cells and IL-33 was recently discovered to be its ligand. We measured serum levels of soluble ST2 (sST2) and IL-33 across the mid-first trimester and examined whether levels were dysregulated among women with a viable fetus but destined to miscarry. While there was no significant change in sST2 or IL-3 across the first trimester, we found that women with live pregnancies destined to fail had dysregulated levels of serum IL-33, and potentially sST2 at six weeks' gestation. (C) 2012 Elsevier Ireland Ltd. All rights reserved.