Prevalence, Serotype Distribution and Antimicrobial Resistance of Non-Typhoidal Salmonella in Hospitalized Patients in Conghua District of Guangzhou, China.
Prevalence, Serotype Distribution and Antimicrobial Resistance of Non-Typhoidal Salmonella in Hospitalized Patients in Conghua District of Guangzhou, China.
复制标题
广州市从化区住院患者非伤寒沙门氏菌患病率、血清型分布及耐药性分析
DOI：
10.3389/fcimb.2022.805384
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发表时间：
2022
影响因子：
5.7
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Gong B;Li H;Feng Y;Zeng S;Zhuo Z;Luo J;Chen X;Li X
沙门氏菌感染是全世界主要的公共卫生问题，增加了卫生系统的经济负担。非伤寒沙门氏菌 (NTS) 是人类细菌性肠炎的常见原因，每年在全球引起 9380 万例胃肠炎病例，造成 155,000 人死亡。广州市位于中国南部，属亚热带气候，高温和强降雨有利于NTS的传播。然而，广州最大的行政区从化区尚无人类感染NTS的信息。为了解调查地区人群NTS感染情况、血清型分布、危险因素及耐药情况，对广州市从化区住院患者进行了流行病学调查。共采集住院患者粪便标本255份（每人一份），为每位参与者提供一份调查问卷，通过培养鉴定NTS感染，并通过玻片凝集试验确认血清型。观察到的平均患病率为 20.39% (52/255)，并确定了三个血清群：血清群 B (n = 46)、血清群 C1 (n = 4) 和血清群 D1 (n = 2)。其中，鼠伤寒沙门氏菌（n = 39）是最常见的血清型。据观察，3岁以下儿童的NTS感染率在统计学上高于成人（25.15% vs 4.65%，P = 0.006）；人工喂养儿童的患病率统计上高于母乳喂养儿童（30.77% vs 8.33%，P = 0.044）。耐药性检测显示，大多数菌株对氨苄青霉素耐药（92.16%），其中47.06%的菌株具有多重耐药性。因此，有必要持续监测并合理使用抗生素，这将有助于减少耐药菌株的流行。这些数据将有助于制定有效的控制策略来干预和预防沙门氏菌病的发生。
Salmonella infection is a major public health concern worldwide, has contributed to an increased economic burden on the health systems. Non-typhoidal Salmonella (NTS) is a common cause of bacterial enteritis in humans, causing 93.8 million cases of gastroenteritis globally each year, with 155,000 deaths. Guangzhou city is situated in the south of China and has a sub-tropical climate, the heat and heavy rainfall helps the spread of NTS. However, no information of NTS infection is available in humans in Conghua District, the largest administrative district of Guangzhou. To understand the prevalence, serotype distribution, risk factors and drug resistance of NTS infection in humans in the survey area, an epidemiological investigation was conducted in hospitalized patients in Conghua District in Guangzhou, China. A total of 255 fecal specimens were collected from hospitalized patients (one each), with a questionnaire for each participant, and NTS infection was identified by culture, as well as serotypes confirmed by slide agglutination tests. An average prevalence of 20.39% (52/255) was observed and three serogroups were identified—serogroup B (n = 46), serogroup C1 (n = 4) and serogroup D1 (n = 2). Among them, Salmonella Typhimurium (n = 39) was the most common serotype. Children aged <3 years were observed to have a statistically higher prevalence of NTS infection than adults (25.15% versus 4.65%, P = 0.006); children with artificial feeding had a statistically higher prevalence than those with breastfeeding (30.77% versus 8.33%, P = 0.044). Antimicrobial resistance testing revealed that the majority of strains were resistant to ampicillin (92.16%), as well as 47.06% of all strains were multi-drug resistant. Therefore, it is necessary to continuous monitoring and rational use of antibiotics, which will be helpful to reduce the prevalence of resistant strains. These data will aid in making efficient control strategies to intervene with and prevent occurrence of salmonellosis.