Human Adaptive Natural Killer Cells: Beyond NKG2C.

Human Adaptive Natural Killer Cells: Beyond NKG2C.
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DOI:
10.1016/j.it.2016.05.001
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发表时间:
2016-06
影响因子:
16.8
通讯作者:
Fehniger TA
Fehniger TA
中科院分区:
医学1区
文献类型:
--
作者:
Wagner JA;Fehniger TA

文献摘要

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范式转变研究已经在感染巨细胞病毒的个体中发现了NKG 2C+适应性自然杀伤(NK)细胞。最近在Cell Reports中,Liu等人证明NKG 2C −/−HCMV+个体也产生适应性NK细胞,并揭示CD 2是这些NK细胞的主要共刺激受体,这些NK细胞专门通过FcγRIIIa/CD 16应答。
Paradigm-shifting studies have identified NKG2C+adaptive natural killer (NK) cells in individuals infected with cytomegalovirus. Recently inCell Reports, Liuet al.demonstrate that NKG2C−/−HCMV+individuals also generate adaptive NK cells, and reveal CD2 as a major co-stimulatory receptor for these NK cells specialized to respond via FcγRIIIa/CD16.