Validity Evidence for the Research Category, "Cognitively Unimpaired - Declining," as a Risk Marker for Mild Cognitive Impairment and Alzheimer's Disease.
Validity Evidence for the Research Category, "Cognitively Unimpaired - Declining," as a Risk Marker for Mild Cognitive Impairment and Alzheimer's Disease.
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DOI：
10.3389/fnagi.2021.688478
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发表时间：
2021
影响因子：
4.8
通讯作者：
Johnson SC
中科院分区：
文献类型：
--
作者：
Langhough Koscik R;Hermann BP;Allison S;Clark LR;Jonaitis EM;Mueller KD;Betthauser TJ;Christian BT;Du L;Okonkwo O;Birdsill A;Chin N;Gleason C;Johnson SC
虽然临床上显著的认知障碍是阿尔茨海默病（AD）连续体的症状阶段的关键特征，但现在已知在进行轻度认知障碍（MCI）或AD所致痴呆的临床诊断之前数年发生轻微认知下降。本研究的主要目的是检查威斯康星州阿尔茨海默病预防登记处（WRAP）中“认知未受损-下降”（CU-D）操作定义的标准有效性证据，该登记处是一项纵向队列研究，跟踪中年和中年的认知和风险因素。多学科小组首先审查病例以确定是否存在MCI或痴呆，随后确定是否存在CU-D。CU-D组在认知的同时测量上不同于CU稳定（CU-S）和MCI，证明了同时有效性。在下一次研究访视时从CU-S变为CU-D的参与者比保持CU-S的参与者表现出更大的下降。此外，CU-D患者比CU-S患者更容易进展为MCI或痴呆（预测有效性）。在正电子发射断层扫描（PET）成像的子样本中，CU-D组在淀粉样蛋白和tau负荷的测量上也与CU-S和MCI/痴呆组不同，表明AD的生物标志物证据在显示亚临床（CU-D）下降的患者中升高。总之，这些结果证实了其他研究，这些研究表明，认知能力下降早在痴呆症诊断之前就开始了，并表明操作标准可以检测到亚临床下降，这可能是AD或其他痴呆症风险的信号。
While clinically significant cognitive impairment is the key feature of the symptomatic stages of the Alzheimer’s disease (AD) continuum, subtle cognitive decline is now known to occur years before a clinical diagnosis of mild cognitive impairment (MCI) or dementia due to AD is made. The primary aim of this study was to examine criterion validity evidence for an operational definition of “cognitively unimpaired-declining” (CU-D) in the Wisconsin Registry for Alzheimer’s Prevention (WRAP), a longitudinal cohort study following cognition and risk factors from mid-life and on. Cognitive status was determined for each visit using a consensus review process that incorporated internal norms and published norms; a multi-disciplinary panel reviewed cases first to determine whether MCI or dementia was present, and subsequently whether CU-D was present, The CU-D group differed from CU-stable (CU-S) and MCI on concurrent measures of cognition, demonstrating concurrent validity. Participants who changed from CU-S to CU-D at the next study visit demonstrated greater declines than those who stayed CU-S. In addition, those who were CU-D were more likely to progress to MCI or dementia than those who were CU-S (predictive validity). In a subsample with positron emission tomography (PET) imaging, the CU-D group also differed from the CU-S and MCI/Dementia groups on measures of amyloid and tau burden, indicating that biomarker evidence of AD was elevated in those showing sub-clinical (CU-D) decline. Together, the results corroborate other studies showing that cognitive decline begins long before a dementia diagnosis and indicate that operational criteria can detect subclinical decline that may signal AD or other dementia risk.
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影响因子：
29
作者：
Donohue, Michael C.;Sperling, Reisa A.;Salmon, David P.;Rentz, Dorene M.;Raman, Rema;Thomas, Ronald G.;Weiner, Michael;Aisen, Paul S.
通讯作者：
Aisen, Paul S.
影响因子：
22.4
作者：
CLIFF, N
通讯作者：
CLIFF, N
DOI：
10.1097/jgp.0b013e31819431d5
发表时间：
2009-05
期刊：
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子：
--
作者：
Jak AJ;Bondi MW;Delano-Wood L;Wierenga C;Corey-Bloom J;Salmon DP;Delis DC
通讯作者：
Delis DC
DOI：
10.1016/j.jalz.2018.09.008
发表时间：
2019-03
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Clark LR;Koscik RL;Allison SL;Berman SE;Norton D;Carlsson CM;Betthauser TJ;Bendlin BB;Christian BT;Chin NA;Asthana S;Johnson SC
通讯作者：
Johnson SC
影响因子：
2.9
作者：
Cooper, Sally-Ann;McLean, Gary;Morrison, Jill
通讯作者：
Morrison, Jill