Adult rats exposed to early-life social isolation exhibit increased anxiety and conditioned fear behavior, and altered hormonal stress responses
Adult rats exposed to early-life social isolation exhibit increased anxiety and conditioned fear behavior, and altered hormonal stress responses
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DOI：
10.1016/j.yhbeh.2008.10.014
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发表时间：
2009-01-01
影响因子：
3.5
通讯作者：
Forster, Gina L.
中科院分区：
文献类型：
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作者：
Lukkes, Jodi L.;Mokin, Maxim V.;Forster, Gina L.
啮齿类动物在发育过程中的社会隔离被认为是早期慢性应激的相关模型。我们研究了雄性大鼠早期社会隔离对成年后恐惧和焦虑行为以及皮质酮应激反应的影响。在出生后第21天，将雄性大鼠单独饲养或3只一组饲养3周，之后，将所有大鼠再分组饲养2周。治疗5周后，检测成年大鼠对束缚应激的条件性恐惧、开放性Held焦虑样行为、社会交往行为和皮质酮反应。与组养大鼠相比，分离株在试验期的前10分钟内在明亮的开放场地中表现出增加的焦虑样行为。隔离饲养的大鼠在社会互动测试中也表现出恐惧行为增加和社会接触减少，以及对预测足部电击的条件刺激的恐惧行为短暂增加。隔离饲养的大鼠表现出类似的限制诱导的血浆皮质酮增加组饲养的控制，但血浆皮质酮水平2小时后限制显着低于预应力水平的隔离。总的来说，这项研究表明，隔离限制在早期的发展增加了焦虑和恐惧的行为在成年期，也导致血浆皮质酮水平下降后的约束压力。(C)2008年爱思唯尔公司All rights reserved.
Social isolation of rodents during development is thought to be a relevant model of early-life chronic stress. We investigated the effects of early-life social isolation on later adult fear and anxiety behavior, and on corticosterone stress responses, in male rats. On postnatal day 21, male rats were either housed in isolation or in groups of 3 for a 3 week period, after which, all rats were group-reared for an additional 2 weeks. After the 5-week treatment, adult rats were examined for conditioned fear, open Held anxiety-like behavior, social interaction behavior and corticosterone responses to restraint stress. Isolates exhibited increased anxiety-like behaviors in a brightly-lit open field during the first 10 min of the test period compared to group-reared rats. Isolation-reared rats also showed increased fear behavior and reduced social contact in a social interaction test, and a transient increase in fear behavior to a conditioned stimulus that predicted foot-shock. Isolation-reared rats showed similar restraint-induced increases in plasma corticosterone as group-reared controls, but plasma corticosterone levels 2 h after restraint were significantly lower than pre-stress levels in isolates. Overall, this study shows that isolation restricted to an early part of development increases anxiety-like and fear behaviors in adulthood, and also results in depressed levels of plasma corticosterone following restraint stress. (C) 2008 Elsevier Inc. All rights reserved.