The sand rat model for disc degeneration: Radiologic characterization of age-related changes - Cross-sectional and prospective analyses
The sand rat model for disc degeneration: Radiologic characterization of age-related changes - Cross-sectional and prospective analyses
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DOI：
10.1097/00007632-200202010-00004
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发表时间：
2002-02-01
期刊：
影响因子：
3
通讯作者：
Hanley, EN
中科院分区：
文献类型：
--
作者：
Gruber, HE;Johnson, T;Hanley, EN
研究设计。本报告由两项研究组成，一项横断面研究和一项前瞻性队列研究，分析沙鼠(Psamomys Obesus)椎间盘退变的放射学特征。通过对单个动物的横断面研究和前瞻性月度评估，对这一有用的动物模型中的进行性椎间盘退变进行统计学评估。Obeesus是一种有吸引力的自发性年龄相关性椎间盘退变的小型啮齿动物模型。由于椎间盘退变是自发的，该模型避免了使用化学髓核溶解术或手术损伤来导致椎间盘退变。然而，对于进行性椎间盘恶化的具体细节了解甚少。这项研究在横断面研究中对158只动物进行了统计评估，在纵向研究中对22只动物进行了跟踪调查，直到12个月大。影像表现包括：椎间盘边缘不规则、椎间盘楔入、椎体变窄、终板钙化、软骨下硬化、韧带钙化和骨赘形成。所有特征都存在与年龄相关的显著横断面变化(P<0.005)。与女性相比，男性在6个月和12个月、2个月和6个月时楔入和终板钙化的发生率在统计学上更高。然而，在6个月大的时候，雌性终板钙化的发生率高于配偶。前瞻性分析显示，12个月时椎体楔形、狭窄、终板钙化和边缘不规则的情况比2个月时更常见(P=0.0001)。到12月龄时，雄性和雌性的所有腰椎部位都出现终板钙化，大多数动物表现为狭窄和楔形。退变的X线征象在2个月大时明显；楔形、狭窄、不规则的椎间盘边缘和终板钙化是老年动物最常见的退行性改变。这些数据表明，沙鼠提供了一种可靠的、有用的自发性椎间盘退变模型。
Study Design. This report is composed of two studies, one cross-sectional and one prospective cohort study, that analyze the radiologic features of disc degeneration in the sand rat (Psammomys obesus).Objectives. To statistically assess progressive disc degeneration in this useful animal model in terms of a cross-sectional study and a prospective monthly evaluation of individual animals.Summary of Background Data. A obesus is an attractive small rodent model for spontaneous age-related disc degeneration. Because disc degeneration is spontaneous, the model avoids use of chemonucleolysis or surgical injury to cause disc degeneration. Little is understood, however, about specific details of the progressive disc deterioration.Methods. This study statistically assessed 158 animals in a cross-sectional study and 22 animals in a longitudinal study, which followed individual animals to 12 months of age. Radiologic features involving irregular disc margins, disc wedging, disc narrowing, endplate calcification, subchondral sclerosis, ligament calcification, and osteophyte formation were studied.Results. Significant age-related cross-sectional changes were present for all features (P less than or equal to 0.005). Males showed a statistically greater incidence of wedging at 6 and 12 months, wedging at 2 and 6 months, and endplate calcification at 2 months than did females. By 6 months of age, however, endplate calcification had a higher incidence in females than in mates. Prospective analysis showed that wedging, narrowing, endplate calcification, and irregular disc margins were more common at 12 months of age than at 2 months (P = 0.0001). By the age of 12 months, all lumbar sites of both males and females showed endplate calcification and the majority of animals showed narrowing and wedging.Conclusions. Radiographic signs of degeneration were evident by age 2 months; wedging, narrowing, irregular disc margins, and endplate calcification were the most common degenerative changes in older animals. These data show that the sand rat provides a reliable, useful model of spontaneous disc degeneration.