Prevalence and risk factors for ocular surface disease among patients treated over the long term for glaucoma or ocular hypertension
Prevalence and risk factors for ocular surface disease among patients treated over the long term for glaucoma or ocular hypertension
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DOI：
10.5301/ejo.5000181
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发表时间：
2013-01-01
影响因子：
1.7
通讯作者：
Bouee, Stephane
中科院分区：
文献类型：
--
作者：
Baudouin, Christophe;Renard, Jean-Paul;Bouee, Stephane
目的.确定眼表疾病的患病率并确定长期接受抗青光眼眼药水治疗的患者人群的危险因素。一项观察性横断面研究旨在使用简单的临床工具研究眼表体征和症状。根据10个关于眼表症状和体征的问题，采用4级量表计算眼表疾病强度评分。根据总评分将患者分为3组（A、B和C）。进行多项逻辑回归以确定表面疾病的危险因素。在516例患者的总体人群中，49%属于A组，30%属于B组，21%属于C组。多因素分析显示，以下因素与眼表疾病的严重程度相关：患者年龄、每日滴眼液次数、既往眼不耐受的局部治疗变化（40%患者的病史中发现）、眼内压（发现眼表疾病更严重的患者眼内压显著更高）和青光眼严重程度。接受原发性开角型青光眼或高眼压治疗的患者通常患有眼表疾病，在接受更多药物治疗的老年患者中更常见且更严重，并表现出更严重的青光眼。因此，这些高流行率值可能会在坚持治疗和生活质量方面对疾病负担产生影响。
PURPOSE. To determine the prevalence of ocular surface diseases and identify risk factors in a population of patients receiving antiglaucomatous eyedrops over the long term.METHODS. An observational cross-sectional study was designed to investigate ocular surface signs and symptoms using simple clinical tools. An ocular surface disease intensity score was calculated based on 10 questions regarding ocular surface symptoms and signs with a 4-grade scale. Patients were classified into 3 groups (A, B, and C) according to this total score. A multinomial logistic regression was performed in order to identify risk factors for surface disease.RESULTS. In an overall population of 516 patients, 49% belonged to group A, 30% to group B, and 21% to group C. The multivariate analysis showed that the following factors were correlated with the severity of ocular surface disease: patient age, number of daily eyedrops, past topical treatment changes for ocular intolerance (found in the history of 40% of the patients), intraocular pressure (found to be significantly higher in patients with more severe ocular surface disease), and glaucoma severity.CONCLUSIONS. Patients treated for primary open-angle glaucoma or ocular hypertension often have ocular surface diseases, more often and more severely in older patients receiving more drugs and presenting with more severe glaucoma. These high prevalence values might therefore have consequences on the burden of the disease in terms of adherence to treatment and quality of life.