Cellular uptake and cytotoxicity of silica nanotubes
Cellular uptake and cytotoxicity of silica nanotubes
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DOI：
10.1021/nl0802741
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发表时间：
2008-08-01
期刊：
影响因子：
10.8
通讯作者：
Ghandehari, Hamidreza
中科院分区：
文献类型：
--
作者：
Nan, Anjan;Bai, Xia;Ghandehari, Hamidreza
“模板合成的”二氧化硅纳米管（SNT）提供独特的特征，例如末端官能化以控制药物释放，用于装载生物分子的内部空隙，以及可以针对靶向和生物相容性进行差异官能化的独特的内表面和外表面。关于它们的生物相互作用的信息非常有限。这项工作评估的影响的大小和表面电荷的SNTs细胞毒性和摄取。结果还表明，内吞是一种可能的机制内化的SNTs。
"Template synthesized" silica nanotubes (SNTs) provide unique features such as end functionalization to control drug release, inner voids for loading biomolecules, and distinctive inner and outer surfaces that can be differentially functionalized for targeting and biocompatibility. Very limited information is available about their biological interactions. This work evaluates the influence of size and surface charge of SNTs on cellular toxicity and uptake. Results additionally indicate endocylosis to be one possible mechanism of internalization of SNTs.