Physiological perspectives on leptin as a regulator of reproduction: Role in timing puberty
Physiological perspectives on leptin as a regulator of reproduction: Role in timing puberty
复制标题
DOI：
10.1095/biolreprod60.2.205
复制
发表时间：
1999-02-01
影响因子：
3.6
通讯作者：
Nagatani, S
中科院分区：
文献类型：
--
作者：
Foster, DL;Nagatani, S
营养如何调节生殖活动仍然是生殖生物学中一个尚未解决的主要问题。在成年期降低营养水平可能导致不孕，主要是通过减少GnRH分泌。对这一机制的探究源于对生育开始时间的线索的探索，因为性成熟的克里思与身体发育的关系比与实际年龄的关系更密切。生长取决于食物摄入的数量和质量。当食物供应不足时，新陈代谢高、生长缓慢的小而短命的物种甚至可能在死亡前还没有进入青春期。在寿命较长的物种中，青春期会推迟数月甚至数年，直到有更多的食物可用。为了充分理解青春期进展是如何计时的，需要了解大脑如何感知与能量代谢相关的外周信号，以及这些信息如何通过控制GnRH分泌的途径。在这里，我们提供了一些背景和生理角度的问题，是否脂肪衍生的激素瘦素是唯一的外周信号，是一个重要的信号，只是一个星座的信号，或不是一个信号定时青春期。
How nutrition regulates reproductive activity remains a major unsolved question of reproductive biology. Reducing the level of nutrition during adulthood can lead to infertility, primarily through reduction of GnRH secretion. Inquiry about such a mechanism has its roots in the search for cues timing the onset of fertility, because the tempo of sexual maturation is much more closely associated with body growth than with chronological age. Growth depends on the quantity and quality of food intake. When food availability is low, small, short-lived species with high metabolism and reduced growth may not even attain puberty before they die. In longer-lived species, puberty is delayed for months or even years until more food becomes available. To appreciate fully how the pubertal progression is timed will require understanding how peripheral signals relating information about energy metabolism are sensed by the brain and how such information is routed through pathways controlling GnRH secretion. Here, we provide some background and physiologic perspective on the question of whether the fat-derived hormone leptin is the unique peripheral signal, is an important signal, is but one of a constellation of signals, or is not a signal timing puberty.