Minimizing noise in pediatric task-based functional MRI; Adolescents with developmental disabilities and typical development.
Minimizing noise in pediatric task-based functional MRI; Adolescents with developmental disabilities and typical development.
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DOI：
10.1016/j.neuroimage.2017.01.021
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发表时间：
2017-04-01
期刊：
影响因子：
5.7
通讯作者：
Schweitzer JB
中科院分区：
文献类型：
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作者：
Fassbender C;Mukherjee P;Schweitzer JB
功能磁共振成像(FMRI)是一种强大的工具，可以用来检查典型发育中的儿科群体以及患有临床疾病的儿童和青少年的大脑功能和发育。然而，由于过度噪音的影响，fMRI数据可能非常容易被误解，噪音水平通常与头部运动有关。对儿童进行成像，特别是患有发育障碍的儿童，需要额外考虑与多动、焦虑以及执行和保持对fMRI范式的注意的能力有关的问题。我们讨论了一些可以用来最小化噪声的方法，特别是与运动相关的噪声。为此，我们将重点放在主要在我们自己的实验室内采用的数据获取阶段之前、期间和之后的战略。我们讨论了实验设计、潜在参与者的筛选和扫描前训练等因素对患有发育障碍和典型发育的青少年头部运动的影响。我们提出了一些建议，可以最大限度地减少数据采集本身的噪声，最后我们简要讨论了一些当前的处理技术，这些技术可能有助于识别和消除数据中的噪声。在儿科成像领域取得了许多进展，特别是在涉及发育障碍儿童的研究方面。对这里讨论的这些问题的关注将确保研究的持续进展和更大的一致性。
Functional Magnetic Resonance Imaging (fMRI) represents a powerful tool with which to examine brain functioning and development in typically developing pediatric groups as well as children and adolescents with clinical disorders. However, fMRI data can be highly susceptible to misinterpretation due to the effects of excessive levels of noise, often related to head motion. Imaging children, especially with developmental disorders, requires extra considerations related to hyperactivity, anxiety and the ability to perform and maintain attention to the fMRI paradigm. We discuss a number of methods that can be employed to minimize noise, in particular movement-related noise. To this end we focus on strategies prior to, during and following the data acquisition phase employed primarily within our own laboratory. We discuss the impact of factors such as experimental design, screening of potential participants and pre-scan training on head motion in our adolescents with developmental disorders and typical development. We make some suggestions that may minimize noise during data acquisition itself and finally we briefly discuss some current processing techniques that may help to identify and remove noise in the data. Many advances have been made in the field of pediatric imaging, particularly with regard to research involving children with developmental disorders. Mindfulness of issues such as those discussed here will ensure continued progress and greater consistency across studies.