The bactericidal effect of silver nanoparticles
The bactericidal effect of silver nanoparticles
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DOI：
10.1088/0957-4484/16/10/059
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发表时间：
2005-10-01
期刊：
影响因子：
3.5
通讯作者：
Yacaman, MJ
中科院分区：
文献类型：
--
作者：
Morones, JR;Elechiguerra, JL;Yacaman, MJ
预计纳米技术将开辟新的途径，以打击和预防疾病使用原子尺度剪裁的材料。具有抗菌性能的最有前途的纳米材料之一是金属纳米颗粒，由于其大的表面体积比和晶体表面结构，其表现出增加的化学活性。考虑到最近细菌对最有效抗生素的新耐药菌株的增加，杀菌纳米材料的研究特别及时。这促进了对包括银纳米颗粒在内的银离子和基于银的化合物的公知活性的研究。本工作使用高角度环形暗场（HAADF）扫描透射电子显微镜（STEM）研究了1-100 nm范围内的银纳米颗粒对革兰氏阴性菌的影响。我们的研究结果表明，纳米颗粒的杀菌性能是大小依赖性的，因为唯一的纳米颗粒，目前与细菌的直接相互作用，优先具有类似的直径为1-10 nm。
Nanotechnology is expected to open new avenues to fight and prevent disease using atomic scale tailoring of materials. Among the most promising nanomaterials with antibacterial properties are metallic nanoparticles, which exhibit increased chemical activity due to their large surface to volume ratios and crystallographic surface structure. The study of bactericidal nanomaterials is particularly timely considering the recent increase of new resistant strains of bacteria to the most potent antibiotics. This has promoted research in the well known activity of silver ions and silver-based compounds, including silver nanoparticles. The present work studies the effect of silver nanoparticles in the range of 1-100 nm on Gram-negative bacteria using high angle annular dark field (HAADF) scanning transmission electron microscopy (STEM). Our results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of similar to 1-10 nm.